Multidisciplinary Analysis of a Nontoxigenic Clostridium difficile Strain with Stable Resistance to Metronidazole

被引：33

作者：

Moura, Ines ^{[1
]}

Monot, Marc ^{[2
]}

Tani, Chiara ^{[3
]}

Spigaglia, Patrizia ^{[1
]}

Barbanti, Fabrizio ^{[1
]}

Norais, Nathalie ^{[3
]}

Dupuy, Bruno ^{[2
]}

Bouza, Emilio ^{[4
]}

Mastrantonio, Paola ^{[1
]}

机构：

[1] Ist Super Sanita, Dept Infect Parasit & Immune Mediated Dis, I-00161 Rome, Italy

[2] Inst Pasteur, Lab Pathogenese Bacteries Anaerobies, Paris, France

[3] Novartis Vaccines & Diagnost, Struct Mass Spectrometry & Prote Unit, Siena, Italy

[4] Hosp Gen Univ Gregorio Maranon, Madrid, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2014年 / 58卷 / 08期

关键词：

ESCHERICHIA-COLI; SUSCEPTIBILITY;

D O I：

10.1128/AAC.02350-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Stable resistance to metronidazole in a nontoxigenic Clostridium difficile strain was investigated at both the genomic and proteomic levels. Alterations in the metabolic pathway involving the pyruvate-ferredoxin oxidoreductase were found, suggesting that reduction of metronidazole, required for its activity, may be less efficient in this strain. Proteomic studies also showed a cellular response to oxidative stress.

引用

页码：4957 / 4960

页数：4

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