Palladium Nanoparticle-Catalyzed Direct Ethynylation of Aliphatic Carboxylic Acid Derivatives via C(sp3)-H Bond Functionalization

被引：49

作者：

Al-Amin, Mohammad ^{[1
]}

Arisawa, Mitsuhiro ^{[1
]}

Shuto, Satoshi ^{[1
]}

Ano, Yusuke ^{[2
]}

Tobisu, Mamoru ^{[2
]}

Chatani, Naoto ^{[2
]}

机构：

[1] Hokkaido Univ, Fac Pharmaceut Sci, Kita Ku, Sapporo, Hokkaido 0600812, Japan

[2] Osaka Univ, Dept Appl Chem, Fac Engn, Suita, Osaka 5650871, Japan

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2014年 / 356卷 / 07期

关键词：

alkynylation; CH bond functionalization; nanoparticles; palladium; recyclable catalysts; GOLD-SUPPORTED PALLADIUM; C-H FUNCTIONALIZATION; DIRECT ARYLATION; ACTIVATION; ALKENYLATION; ALKYLATION; MOLECULES; OXIDATION; DIOXYGEN;

D O I：

10.1002/adsc.201301180

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

We have developed a sulfur-modified, gold-supported palladium material (SAuPd) with palladium, Pd, nanoparticles on its surface; it is a recyclable, low-leaching Pd catalyst. Here we report, using SAuPd, the first example of Pd nanoparticle-catalyzed, unactivated C(sp(3))H bond functionalization of amides, using 8-aminoquinoline as a directing group, to yield ethynylated products. The low leaching properties of SAuPd enabled it to be recycled and reused 10 times for C(sp(3))H bond functionalization.

引用

页码：1631 / 1637

页数：7

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