The interplay between mitochondria and autophagy and its role in the aging process

被引：55
作者：
Schiavi, Alfonso [3 ,4 ]
Ventura, Natascia [1 ,2 ,3 ,4 ]
机构：
[1] Univ Dusseldorf, Fac Med, Inst Clin Chem, Dusseldorf, Germany
[2] Univ Dusseldorf, Fac Med, Diagnost Lab, Dusseldorf, Germany
[3] IUF, Leibniz Res Inst Environm Med, Dusseldorf, Germany
[4] Univ Roma Tor Vergata, I-00133 Rome, Italy
来源：
EXPERIMENTAL GERONTOLOGY | 2014年 / 56卷
关键词：
Aging; Autophagy; C; elegans; Diseases; Mitochondria; Mitophagy; Hormesis; EXTENDS LIFE-SPAN; VITAMIN-E SUPPLEMENTATION; SYSTEMATIC RNAI SCREEN; FREE-RADICAL THEORY; CAENORHABDITIS-ELEGANS; CALORIC RESTRICTION; OXIDATIVE STRESS; QUALITY-CONTROL; DNA-DAMAGE; DIETARY RESTRICTION;
D O I：
10.1016/j.exger.2014.02.015
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Mitochondria are highly dynamic organelles which play a central role in cellular homeostasis. Mitochondrial dysfunction leads to life-threatening disorders and accelerates the aging process. Surprisingly, on the other hand, a mild reduction of mitochondria functionality can have pro-longevity effects in organisms spanning from yeast to mammals. Autophagy is a fundamental cellular housekeeping process that needs to be finely regulated for proper cell and organism survival, as underlined by the fact that both its over- and its defective activation have been associated with diseases and accelerated aging. A reciprocal interplay exists between mitochondria and autophagy, which is needed to constantly adjust cellular energy metabolism in different pathophysiological conditions. Here we review general features of mitochondrial function and autophagy with particular focus on their crosstalk and its possible implication in the aging process. (C) 2014 Elsevier Inc. All rights reserved.
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收藏
页码：147 / 153
页数：7
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