Decoding pseudouridine: an emerging target for therapeutic development

被引：78
作者：
Cerneckis, Jonas [1 ,2 ]
Cui, Qi [1 ]
He, Chuan [3 ,4 ]
Yi, Chengqi [5 ]
Shi, Yanhong [1 ,2 ]
机构：
[1] Beckman Res Inst City Hope, Dept Stem Cell Biol & Regenerat Med, Div Stem Cell Biol Res, Duarte, CA 91010 USA
[2] Beckman Res Inst City Hope, Irell & Manella Grad Sch Biol Sci, Duarte, CA 91010 USA
[3] Univ Chicago, Howard Hughes Med Inst, Dept Chem, Dept Biochem & Mol Biol, Chicago, IL 60637 USA
[4] Univ Chicago, Inst Biophys Dynam, Howard Hughes Med Inst, Chicago, IL 60637 USA
[5] Peking Univ, Sch Life Sci & Peking Tsinghua Ctr Life Sci, State Key Lab Prot & Plant Gene Res, Beijing, Peoples R China
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 2022年 / 43卷 / 06期
关键词：
SMALL-NUCLEOLAR RNAS; MESSENGER-RNA; DYSKERATOSIS-CONGENITA; TRANSLATIONAL CONTROL; MEDIATED TRANSLATION; CANCER; DYSKERIN; MUTATION; BINDING; YEAST;
D O I：
10.1016/j.tips.2022.03.008
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Pseudouridine (LP) is the most abundant post-transcriptional RNA modification and is widespread in multiple RNA species. LP impacts various aspects of RNA biology, conferring distinct structural and functional properties to the RNA molecules that it decorates. However, aberrant pseudouridylation contributes to a variety of human diseases, including cancer and genetic disorders. Dysregulation of the LP epitranscriptome can arise from mutations and abnormal expression of pseudouridylation machinery, impacting protein translation and other cellular processes. With advancing understanding of LP roles in health and disease, efforts are now invested in developing therapeutic and diagnostic approaches targeting LP. Emerging reports indicate that LP and its installation machinery could be potential pharmacological targets for therapeutic development and may serve as biomarkers for human diseases.
引用
收藏
页码：522 / 535
页数：14
相关论文
共 101 条
[1]   HIV "shock and kill" therapy: In need of revision [J].
Abner, Erik ;
Jordan, Albert .
ANTIVIRAL RESEARCH, 2019, 166 :19-34
[2]   Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation [J].
Anderson, Bart R. ;
Muramatsu, Hiromi ;
Nallagatla, Subba R. ;
Bevilacqua, Philip C. ;
Sansing, Lauren H. ;
Weissman, Drew ;
Kariko, Katalin .
NUCLEIC ACIDS RESEARCH, 2010, 38 (17) :5884-5892
[3]   Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy [J].
Archin, N. M. ;
Liberty, A. L. ;
Kashuba, A. D. ;
Choudhary, S. K. ;
Kuruc, J. D. ;
Crooks, A. M. ;
Parker, D. C. ;
Anderson, E. M. ;
Kearney, M. F. ;
Strain, M. C. ;
Richman, D. D. ;
Hudgens, M. G. ;
Bosch, R. J. ;
Coffin, J. M. ;
Eron, J. J. ;
Hazuda, D. J. ;
Margolis, D. M. .
NATURE, 2012, 487 (7408) :482-U1650
[4]   A Pseudouridine Residue in the Spliceosome Core Is Part of the Filamentous Growth Program in Yeast [J].
Basak, Anindita ;
Query, Charles C. .
CELL REPORTS, 2014, 8 (04) :966-973
[5]   Quantitative profiling of pseudouridylation dynamics in native RNAs with nanopore sequencing [J].
Begik, Oguzhan ;
Lucas, Morghan C. ;
Pryszcz, Leszek P. ;
Ramirez, Jose Miguel ;
Medina, Rebeca ;
Milenkovic, Ivan ;
Cruciani, Sonia ;
Liu, Huanle ;
Vieira, Helaine Graziele Santos ;
Sas-Chen, Aldema ;
Mattick, John S. ;
Schwartz, Schraga ;
Novoa, Eva Maria .
NATURE BIOTECHNOLOGY, 2021, 39 (10) :1278-+
[6]   H/ACA Small RNA Dysfunctions in Disease Reveal Key Roles for Noncoding RNA Modifications in Hematopoietic Stem Cell Differentiation [J].
Bellodi, Cristian ;
McMahon, Mary ;
Contreras, Adrian ;
Juliano, Dayle ;
Kopmar, Noam ;
Nakamura, Tomoka ;
Maltby, David ;
Burlingame, Alma ;
Savage, Sharon A. ;
Shimamura, Akiko ;
Ruggero, Davide .
CELL REPORTS, 2013, 3 (05) :1493-1502
[7]   Loss of Function of the Tumor Suppressor DKC1 Perturbs p27 Translation Control and Contributes to Pituitary Tumorigenesis [J].
Bellodi, Cristian ;
Krasnykh, Olya ;
Haynes, Nikesha ;
Theodoropoulou, Marily ;
Peng, Guang ;
Montanaro, Lorenzo ;
Ruggero, Davide .
CANCER RESEARCH, 2010, 70 (14) :6026-6035
[8]   Deregulation of oncogene-induced senescence and p53 translational control in X-linked dyskeratosis congenita [J].
Bellodi, Cristian ;
Kopmar, Noam ;
Ruggero, Davide .
EMBO JOURNAL, 2010, 29 (11) :1865-1876
[9]  
Beneventi G., 2021, NAR CANCER, V3, DOI DOI 10.1093/NARCAN/ZCAB026
[10]   MODOMICS: a database of RNA modification pathways. 2021 update [J].
Boccaletto, Pietro ;
Stefaniak, Filip ;
Ray, Angana ;
Cappannini, Andrea ;
Mukherjee, Sunandan ;
Purta, Elzbieta ;
Kurkowska, Malgorzata ;
Shirvanizadeh, Niloofar ;
Destefanis, Eliana ;
Groza, Paula ;
Avsar, Gulben ;
Romitelli, Antonia ;
Pir, Pinar ;
Dassi, Erik ;
Conticello, Silvestro G. ;
Aguilo, Francesca ;
Bujnicki, Janusz M. .
NUCLEIC ACIDS RESEARCH, 2022, 50 (D1) :D231-D235
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