Dissipative Particle Dynamics Simulation on Paclitaxel Loaded PEO-PPO-PEO Block Copolymer Micelles

被引：11

作者：

Wang, Zhigao ^{[1
]}

Jiang, Jie ^{[2
]}

机构：

[1] Sichuan Elect Power Res Inst, Chengdu 610072, Peoples R China

[2] Chengdu Univ Technol, State Key Lab Geohazard Prevent & Geoenvironm Pro, Coll Environm & Civil Engn, Chengdu 610059, Peoples R China

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2014年 / 14卷 / 03期

关键词：

DPD; Polymer; PEO-PPO-PEO; Micelles; PH-SENSITIVE MICELLES; DRUG-DELIVERY; PHASE-BEHAVIOR; FABRICATION; DOXORUBICIN; COMPOSITES; SYSTEM; CANCER;

D O I：

10.1166/jnn.2014.8468

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Self-assembly behavior of the polymer drug loading micelle PEO-PPO-PEO was studied using dissipative particle dynamics (DPD) simulation method with various simulation steps. The distributions of drugs in polymer carriers were also investigated with different drug feed ratios. Polymer carriers distributed on the surface of the spherical micelle, and drugs were almost encapsulated in the inner of the micelle. Our simulation work demonstrates that the DPD simulation is effective to study the drug loaded systems and can give useful guidance on the design and preparation of new drug carriers with tailored properties.

引用

页码：2644 / 2647

页数：4

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