Boron Nitride Nanotubes Are Noncytotoxic and Can Be Functionalized for Interaction with Proteins and Cells

被引：496

作者：

Chen, Xing ^{[2
,6
]}

Wu, Peng ^{[2
]}

Rousseas, Michael ^{[1
]}

Okawa, David ^{[1
]}

Gartner, Zev ^{[2
]}

Zettl, Alex ^{[1
,6
]}

Bertozzi, Carolyn R. ^{[2
,3
,4
,5
,6
]}

机构：

[1] Univ Calif Berkeley, Dept Phys, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[4] Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA

[5] Univ Calif Berkeley, Lawrence Berkeley Lab, Mol Foundry, Berkeley, CA 94720 USA

[6] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Mat Sci, Berkeley, CA 94720 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 03期

关键词：

WALLED CARBON NANOTUBES; IN-VITRO; SOLUBILIZATION; CYTOTOXICITY; BIOLOGY;

D O I：

10.1021/ja807334b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the discovery that boron nitride nanotubes (BNNTs), isosteres of CNTs with unique physical properties, are inherently noncytotoxic. Furthermore, we developed a biomemetic coating strategy to interface BNNTs with proteins and cells. Finally, we showed that BNNTs can deliver DNA oligomers to the interior of cells with no apparent toxicity. This work suggests that BNNTs may be superior to CNTs for use as biological probes and in biomaterials.

引用

页码：890 / +

页数：4

共 23 条

[1] STABILITY AND BAND-GAP CONSTANCY OF BORON-NITRIDE NANOTUBES [J].

BLASE, X ;

RUBIO, A ;

LOUIE, SG ;

COHEN, ML .

EUROPHYSICS LETTERS, 1994, 28 (05) :335-340

[2] Multi-walled carbon nanotubes induce T lymphocyte apoptosis [J].

Bottini, M ;

Bruckner, S ;

Nika, K ;

Bottini, N ;

Bellucci, S ;

Magrini, A ;

Bergamaschi, A ;

Mustelin, T .

TOXICOLOGY LETTERS, 2006, 160 (02) :121-126

[3] Thermal conductivity of B-C-N and BN nanotubes [J].

Chang, CW ;

Han, WQ ;

Zettl, A .

APPLIED PHYSICS LETTERS, 2005, 86 (17) :1-3

[4] A cell nanoinjector based on carbon nanotubes [J].

Chen, Xing ;

Kis, Andras ;

Zettl, A. ;

Bertozzi, Carolyn R. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (20) :8218-8222

[5] Interfacing carbon nanotubes with living cells [J].

Chen, Xing ;

Tam, Un Chong ;

Czlapinski, Jennifer L. ;

Lee, Goo Soo ;

Rabuka, David ;

Zettl, Alex ;

Bertozzi, Carolyn R. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (19) :6292-6293

[6] BORON-NITRIDE NANOTUBES [J].

CHOPRA, NG ;

LUYKEN, RJ ;

CHERREY, K ;

CRESPI, VH ;

COHEN, ML ;

LOUIE, SG ;

ZETTL, A .

SCIENCE, 1995, 269 (5226) :966-967

[7] Cell surface biology mediated by low affinity multivalent protein-glycan interactions [J].

Collins, BE ;

Paulson, JC .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2004, 8 (06) :617-625

[8] Effect of single wall carbon nanotubes on human HEK293 cells [J].

Cui, DX ;

Tian, FR ;

Ozkan, CS ;

Wang, M ;

Gao, HJ .

TOXICOLOGY LETTERS, 2005, 155 (01) :73-85

[9] Functionalized carbon nanotubes are non-cytotoxic and preserve the functionality of primary immune cells [J].

Dumortier, Helene ;

Lacotte, Stephanie ;

Pastorin, Giorgia ;

Marega, Riccardo ;

Wu, Wei ;

Bonifazi, Davide ;

Briand, Jean-Paul ;

Prato, Maurizio ;

Muller, Sylviane ;

Bianco, Alberto .

NANO LETTERS, 2006, 6 (07) :1522-1528

[10] Elastic properties of C and BxCyNz composite nanotubes [J].

Hernandez, E ;

Goze, C ;

Bernier, P ;

Rubio, A .

PHYSICAL REVIEW LETTERS, 1998, 80 (20) :4502-4505

← 1 2 3 →