A New Way: Alleviating Postembolization Syndrome Following Transcatheter Arterial Chemoembolization

被引:26
作者
Feng Yinglu [1 ]
Ling Changquan [1 ]
Zhai Xiaofeng [1 ]
Li Bai [1 ]
Zhu Dezeng [1 ]
Chen Zhe [1 ]
机构
[1] Hosp Second Mil Med Univ, Dept Tradit Chinese Med Chinghai, Shanghai, Peoples R China
基金
中国国家自然科学基金;
关键词
HEPATOCELLULAR-CARCINOMA; GLUCOCORTICOID-RECEPTOR; PANAX-GINSENG; OILY CHEMOEMBOLIZATION; DOWN-REGULATION; DEXAMETHASONE; STRESS; GINSENOSIDES; EXPRESSION;
D O I
10.1089/acm.2008.0093
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
Background: Currently, most therapies of postembolization syndrome following transcatheter arterial chemoembolization (TACE) aim directly at a single symptom, thus leading to limitations. Objectives: To seek for a systematic approach to prevent and treat the syndrome, we carried out this study to observe the effect of ginsenosides (GS) and dexamethasone (Dex) in alleviating the postembolization syndrome following TACE. Methods: In the randomized, double-blinded and controlled trial, 120 patients with primary liver cancer were divided into 4 groups, with 30 patients in each group. The changes of clinical symptoms and laboratory tests before TACE and on 3 and 7 days after TACE were observed. Results: The results indicated that Dex combined with GS not only markedly decreased the occurrence ratio and duration of such symptoms as nausea, vomiting, and fever, but also significantly reduced levels of total bilirubin, glutamic oxaloacetic transaminase, and glutamic-pyruvic transaminase (AST) and improved the Child-Pugh stage of liver function as compared with single use of GS or Dex. Conclusions: In conclusion, although single use of Dex or GS may improve some indices of adverse effects after TACE, the combination of Dex and GS can systematically prevent and treat the postembolization syndrome following TACE.
引用
收藏
页码:175 / 181
页数:7
相关论文
共 34 条
[1]   STRESS-INDUCED CHANGES OF GLUCOCORTICOID RECEPTOR IN RAT-LIVER [J].
ALEXANDROVA, M ;
FARKAS, P .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1992, 42 (05) :493-498
[2]   Ginseng pharmacology - Multiple constituents and multiple actions [J].
Attele, AS ;
Wu, JA ;
Yuan, CS .
BIOCHEMICAL PHARMACOLOGY, 1999, 58 (11) :1685-1693
[3]   Ginsenosides from Panax ginseng differentially regulate lymphocyte proliferation [J].
Cho, JY ;
Kim, AR ;
Yoo, ES ;
Baik, KU ;
Park, MH .
PLANTA MEDICA, 2002, 68 (06) :497-500
[4]   THERAPEUTIC IVALON EMBOLIZATION OF HEPATIC-TUMORS [J].
CHUANG, VP ;
WALLACE, S ;
SOO, CS ;
CHARNSANGAVEJ, C ;
BOWERS, T .
AMERICAN JOURNAL OF ROENTGENOLOGY, 1982, 138 (02) :289-294
[5]  
COLDWELL DM, 1999, W J MED, V151, P299
[6]  
COLDWELL DM, 1991, REGIONAL CANC TREATM, V3, P298
[7]   Recent insights into the mechanism of glucocorticosteroid-induced apoptosis [J].
Distelhorst, CW .
CELL DEATH AND DIFFERENTIATION, 2002, 9 (01) :6-19
[8]   Defense of adrenocorticosteroid receptor expression in rat hippocampus: Effects of stress and strain [J].
Herman, JP ;
Watson, SJ ;
Spencer, RL .
ENDOCRINOLOGY, 1999, 140 (09) :3981-3991
[9]   ORAL GRANISETRON ALONE AND IN COMBINATION WITH DEXAMETHASONE - A DOUBLE-BLIND RANDOMIZED COMPARISON AGAINST HIGH-DOSE METOCLOPRAMIDE PLUS DEXAMETHASONE IN PREVENTION OF CISPLATIN-INDUCED EMESIS [J].
HERON, JF ;
GOEDHALS, L ;
JORDAAN, JP ;
CUNNINGHAM, J ;
CEDAR, E .
ANNALS OF ONCOLOGY, 1994, 5 (07) :579-584
[10]  
Huang YS, 2002, AM J GASTROENTEROL, V97, P1223