FGF19 subfamily members: FGF19 and FGF21

被引：121
作者：
Dolegowska, Katarzyna [1 ]
Marchelek-Mysliwiec, Malgorzata [1 ]
Nowosiad-Magda, Monika [2 ]
Slawinski, Michal [3 ]
Dolegowska, Barbara [3 ,4 ]
机构：
[1] Pomeranian Med Univ, Clin Dept Nephrol Transplantol & Internal Med, Szczecin, Poland
[2] Pomeranian Med Univ, Dept Immunol Diagnost, Szczecin, Poland
[3] Pomeranian Med Univ, Dept Lab Diagnost, Independent Publ Clin Hosp 2, Szczecin, Poland
[4] Pomeranian Med Univ, Dept Lab Med, Szczecin, Poland
来源：
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY | 2019年 / 75卷 / 02期
关键词：
FGF19; FGF21; Bile acids; Metabolism regulation; Klotho; FIBROBLAST-GROWTH-FACTOR; HEPATIC LIPID-METABOLISM; FATTY LIVER-DISEASE; BETA-KLOTHO; PPAR-ALPHA; BILE-ACID; ADIPOSE; ASSOCIATION; FACTOR-19; FGF-21;
D O I：
10.1007/s13105-019-00675-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Fibroblast growth factors (FGF) constitute a large family of proteins with pleiotropic effects on development, organogenesis, and metabolism. The FGF19 subclass includes growth factors circulating with the blood referred to as endocrine FGF. Representatives of the FGF19 subclass, including FGF19, FGF21, and FGF23, act via FGFR receptors. The proteins of FGF19 subfamily influence the enterohepatic circulation of bile, participate in glucose and lipid metabolism regulation, and maintenance of phosphorus and vitamin D3 homeostasis. FGF19 and FGF21 are activated under different physiological and pathological conditions.
引用
收藏
页码：229 / 240
页数：12
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