Liquid chromatography-mass spectrometry in metabolite profiling

被引：7
|
作者：
Juo, Chiun-Gung [2 ]
Chiu, Daniel Tsun-Yee [3 ,4 ,5 ]
Shiao, Ming-Shi [1 ]
机构：
[1] Chang Gung Univ, Dept Life Sci, Inst Biomed Sci, Tao Yuan, Taiwan
[2] Chang Gung Univ, Mol Med Res Ctr, Tao Yuan, Taiwan
[3] Chang Gung Univ, Grad Inst Med Biotechnol, Tao Yuan, Taiwan
[4] Chang Gung Univ, Dept Med Biotechnol & Lab Sci, Tao Yuan, Taiwan
[5] Chang Gung Mem Hosp, Dept Clin Pathol, Tao Yuan, Taiwan
来源：
BIOFACTORS | 2008年 / 34卷 / 02期
关键词：
Metabolomics; metabolite profiling; UHPLC; LC-MS; ion mobility spectroscopy;
D O I：
10.1002/biof.5520340207
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent advances in the use of liquid chromatography-mass spectrometry for the study of metabolomics are reviewed. Sample preparations of biofluids and practical aspects of ultra-high pressure liquid chromatography are discussed. Applicability of different kinds of mass spectrometers for metabolite profiling is described. New tools-ion mobility spectroscopy and automated chip-based nanoelectrospray system with potentials to be applied in the metabolomics analysis are described.
引用
收藏
页码：159 / 169
页数：11
相关论文
共 50 条
  • [41] Gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry metabolomics platforms: Tools for plant oligosaccharides analysis
    Benkeblia, Noureddine
    CARBOHYDRATE POLYMER TECHNOLOGIES AND APPLICATIONS, 2023, 5
  • [42] A Simplified Liquid Chromatography-Mass Spectrometry Assay for Artesunate and Dihydroartemisinin, Its Metabolite, in Human Plasma
    Teja-Isavadharm, Paktiya
    Siriyanonda, Duangsuda
    Siripokasupkul, Raveewan
    Apinan, Roongnapa
    Chanarat, Nitima
    Lim, Apassorn
    Wannaying, Srisombat
    Saunders, David
    Fukuda, Mark M.
    Miller, Robert S.
    Weina, Peter J.
    Melendez, Victor
    MOLECULES, 2010, 15 (12): : 8747 - 8768
  • [43] Liquid Chromatography-Mass Spectrometry-Based Rapid Secondary-Metabolite Profiling of Marine Pseudoalteromonas sp M2
    Kim, Woo Jung
    Kim, Young Ok
    Kim, Jin Hee
    Nam, Bo-Hye
    Kim, Dong-Gyun
    An, Cheul Min
    Lee, Jun Sik
    Kim, Pan Soo
    Lee, Hye Min
    Oh, Joa-Sup
    Lee, Jong Suk
    MARINE DRUGS, 2016, 14 (01):
  • [44] Untargeted secondary metabolite profiling and putative pathway deduction of a marine Ochrophyte - Iyengaria stellata (Borgesen) using liquid chromatography-mass spectrometry
    Dixit, Dhara
    FOOD BIOSCIENCE, 2023, 51
  • [45] A Tandem Liquid Chromatography-Mass Spectrometry-based Approach for Metabolite Analysis of Staphylococcus aureus
    Samuels, David J.
    Wang, Zhe
    Rhee, Kyu Y.
    Brinsmade, Shaun R.
    JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2017, (121):
  • [46] Comprehensive analysis of lipids in biological systems by liquid chromatography-mass spectrometry
    Cajka, Tomas
    Fiehn, Oliver
    TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2014, 61 : 192 - 206
  • [47] AN OVERVIEW OF MATRIX EFFECTS IN LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY
    Trufelli, Helga
    Palma, Pierangela
    Famiglini, Giorgio
    Cappiello, Achille
    MASS SPECTROMETRY REVIEWS, 2011, 30 (03) : 491 - 509
  • [48] Identification of polymer additives by liquid chromatography-mass spectrometry
    Block, C.
    Wynants, L.
    Kelchtermans, M.
    De Boer, R.
    Compernolle, F.
    POLYMER DEGRADATION AND STABILITY, 2006, 91 (12) : 3163 - 3173
  • [49] Characterization of impurities in tobramycin by liquid chromatography-mass spectrometry
    Li, B.
    Van Schepdael, A.
    Hoogmartens, J.
    Adams, E.
    JOURNAL OF CHROMATOGRAPHY A, 2009, 1216 (18) : 3941 - 3945
  • [50] Urinary metabonomics study in a rat model in response to protein-energy malnutrition by using gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry
    Wu, Zeming
    Li, Min
    Zhao, Chunxia
    Zhou, Jia
    Chang, Yuwei
    Li, Xiang
    Gao, Peng
    Lu, Xin
    Li, Yousheng
    Xu, Guowang
    MOLECULAR BIOSYSTEMS, 2010, 6 (11) : 2157 - 2163
12345