Liquid chromatography-mass spectrometry in metabolite profiling

被引：7
|
作者：
Juo, Chiun-Gung [2 ]
Chiu, Daniel Tsun-Yee [3 ,4 ,5 ]
Shiao, Ming-Shi [1 ]
机构：
[1] Chang Gung Univ, Dept Life Sci, Inst Biomed Sci, Tao Yuan, Taiwan
[2] Chang Gung Univ, Mol Med Res Ctr, Tao Yuan, Taiwan
[3] Chang Gung Univ, Grad Inst Med Biotechnol, Tao Yuan, Taiwan
[4] Chang Gung Univ, Dept Med Biotechnol & Lab Sci, Tao Yuan, Taiwan
[5] Chang Gung Mem Hosp, Dept Clin Pathol, Tao Yuan, Taiwan
来源：
BIOFACTORS | 2008年 / 34卷 / 02期
关键词：
Metabolomics; metabolite profiling; UHPLC; LC-MS; ion mobility spectroscopy;
D O I：
10.1002/biof.5520340207
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent advances in the use of liquid chromatography-mass spectrometry for the study of metabolomics are reviewed. Sample preparations of biofluids and practical aspects of ultra-high pressure liquid chromatography are discussed. Applicability of different kinds of mass spectrometers for metabolite profiling is described. New tools-ion mobility spectroscopy and automated chip-based nanoelectrospray system with potentials to be applied in the metabolomics analysis are described.
引用
收藏
页码：159 / 169
页数：11
相关论文
共 50 条
  • [1] Liquid chromatography-mass spectrometry based global metabolite profiling: A review
    Theodoridis, Georgios A.
    Gika, Helen G.
    Want, Elizabeth J.
    Wilson, Ian D.
    ANALYTICA CHIMICA ACTA, 2012, 711 : 7 - 16
  • [2] Metabolite Profiling of the Antisense Oligonucleotide Eluforsen Using Liquid Chromatography-Mass Spectrometry
    Kim, Jaeah
    Basiri, Babak
    Hassan, Chopie
    Punt, Carine
    van der Hage, Erik
    den Besten, Cathaline
    Bartlett, Michael G.
    MOLECULAR THERAPY-NUCLEIC ACIDS, 2019, 17 : 714 - 725
  • [3] Metabolite profiling of the Cladonia lichens using gas chromatography-mass spectrometry
    Konoreva, Liudmila
    Prokopiev, Ilya
    Frolov, Ivan
    Chesnokov, Sergey
    Rozhina, Sakhayana
    Poryadina, Lena
    Shavarda, Alexey
    BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2019, 85 : 3 - 12
  • [4] High-Performance Liquid Chromatography-Mass Spectrometry-Based Lipid Metabolite Profiling of Acromegaly
    Wang, Meng
    Guo, Shizhe
    He, Min
    Shao, Xiaoqing
    Feng, Lei
    Yu, Yifei
    Gong, Wei
    Liu, Qingfeng
    Melnikov, Vladimir
    Wang, Xiaoxue
    He, Zhian
    Jiang, Lin
    Chen, Maohua
    Sun, Jun
    Cai, Jianyong
    Zhao, Yao
    Li, Yiming
    Tritos, Nicholas A.
    Hu, Zhiyu
    Zhang, Zhaoyun
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2020, 105 (04) : E1075 - E1084
  • [5] Liquid chromatography coupled to mass spectrometry for metabolite profiling in the field of drug discovery
    Saurina, Javier
    Sentellas, Sonia
    EXPERT OPINION ON DRUG DISCOVERY, 2019, 14 (05) : 469 - 483
  • [6] Advances of metabolite identification in liquid chromatography-mass spectrometry based nrietabolomics
    Kong Hongwei
    Dai Weidong
    Xu Guowang
    CHINESE JOURNAL OF CHROMATOGRAPHY, 2014, 32 (10) : 1052 - 1057
  • [7] Comprehensive metabolite profiling of Sinorhizobium meliloti using gas chromatography-mass spectrometry
    Barsch, A.
    Patschkowski, T.
    Niehaus, K.
    FUNCTIONAL & INTEGRATIVE GENOMICS, 2004, 4 (04) : 219 - 230
  • [8] Comprehensive metabolite profiling of Sinorhizobium meliloti using gas chromatography-mass spectrometry
    Aiko Barsch
    Thomas Patschkowski
    Karsten Niehaus
    Functional & Integrative Genomics, 2004, 4 : 219 - 230
  • [9] Metabolite profiling of sucrose effect on the metabolism of Melissa officinalis by gas chromatography-mass spectrometry
    Kim, Sooah
    Shin, Min Hye
    Hossain, Md Aktar
    Yun, Eun Ju
    Lee, Hojoung
    Kim, Kyoung Heon
    ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2011, 399 (10) : 3519 - 3528
  • [10] Metabolite profiling of sucrose effect on the metabolism of Melissa officinalis by gas chromatography-mass spectrometry
    Sooah Kim
    Min Hye Shin
    Md. Aktar Hossain
    Eun Ju Yun
    Hojoung Lee
    Kyoung Heon Kim
    Analytical and Bioanalytical Chemistry, 2011, 399 : 3519 - 3528
12345