Properties of poloxamer 407 and polysorbate mixed micelles: Influence of polysorbate hydrophobic chain

被引：14
作者：
Cirin, Dejan [1 ]
Krstonosic, Veljko [1 ]
Posa, Mihalj [1 ]
机构：
[1] Univ Novi Sad, Fac Med, Dept Pharm, Hajduk Veljkova 3, Novi Sad 21000, Serbia
来源：
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | 2017年 / 47卷
关键词：
Poloxamer; Polysorbate; Mixed micelles; Regular solution theory; Interactions; POLYCYCLIC AROMATIC-HYDROCARBONS; SULFONATE AMPHOTERIC SURFACTANT; BLOCK-COPOLYMER MICELLES; CATIONIC SURFACTANTS; PLURONIC F127; NONIONIC SURFACTANTS; ORAL BIOAVAILABILITY; TRIBLOCK COPOLYMER; BINARY-MIXTURES; TWEEN; 20;
D O I：
10.1016/j.jiec.2016.11.032
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In the present study, binary mixed micelles of poloxamer 407 and a homologous series of polysorbate surfactants (polysorbate 20, polysorbate 60, polysorbate 80, polysorbate 85) were investigated. Rubingh's model was applied to determine the physicochemical parameters of the poloxamer/polysorbate binary systems. The obtained negative values of the interaction parameter and excess Gibbs energy showed the existence of synergism. By comparing the values of the investigated parameters, and the values of micropolarity measurements, it was noticed that the inclusion of polysorbate surfactants with longer and more saturated hydrophobic chains leads to improved packing in the micellar interior and stronger interactions. (C) 2016 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：194 / 201
页数：8
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