Cell membrane-derived nanomaterials for biomedical applications

被引:378
作者
Fang, Ronnie H.
Jiang, Yao
Fang, Jean C.
Zhang, Liangfang [1 ]
机构
[1] Univ Calif San Diego, Dept NanoEngn, La Jolla, CA 92093 USA
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
Cell membrane; Biomimetic nanoparticle; Drug delivery; Immunotherapy; Detoxification; Imaging; ANTIGEN-PRESENTING CELLS; DRUG-DELIVERY VEHICLES; MAGNETIC GLYCO-NANOPARTICLES; IRON-OXIDE NANOPARTICLES; PEPTIDE-BASED VACCINE; HUMAN TASTE RECEPTOR; H-BINDING-PROTEIN; DENDRITIC CELLS; T-CELL; ERYTHROCYTE-MEMBRANE;
D O I
10.1016/j.biomaterials.2017.02.041
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The continued evolution of biomedical nanotechnology has enabled clinicians to better detect, prevent, manage, and treat human disease. In order to further push the limits of nanoparticle performance and functionality, there has recently been a paradigm shift towards biomimetic design strategies. By taking inspiration from nature, the goal is to create next-generation nanoparticle platforms that can more effectively navigate and interact with the incredibly complex biological systems that exist within the body. Of great interest are cellular membranes, which play essential roles in biointerfacing, self identification, signal transduction, and compartmentalization. In this review, we explore the major ways in which researchers have directly leveraged cell membrane-derived biomaterials for the fabrication of novel nanotherapeutics and nanodiagnostics. Such emerging technologies have the potential to significantly advance the field of nanomedicine, helping to improve upon traditional modalities while also enabling novel applications. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码:69 / 83
页数:15
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