Treatment of acute myeloid leukemia with hematopoietic stem cell transplantation

被引：8

作者：

Jones, Cortney V. ^{[1
]}

Copelan, Edward A. ^{[1
]}

机构：

[1] Cleveland Clin, Taussig Canc Inst, Dept Hematol Oncol & Blood Disorders, Acute Leukemia Program, Cleveland, OH 44195 USA

来源：

FUTURE ONCOLOGY | 2009年 / 5卷 / 04期

关键词：

AML; graft-versus-host disease; hematopoietic stem-cell transplantation; remission therapy; stem cells; BONE-MARROW-TRANSPLANTATION; ACUTE MYELOGENOUS LEUKEMIA; VERSUS-HOST-DISEASE; ACUTE MYELOBLASTIC-LEUKEMIA; TOTAL-BODY IRRADIATION; HIGH-DOSE CYTARABINE; ACUTE NONLYMPHOBLASTIC LEUKEMIA; ACUTE NONLYMPHOCYTIC LEUKEMIA; 1ST COMPLETE REMISSION; UMBILICAL-CORD BLOOD;

D O I：

10.2217/FON.09.20

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Allogeneic hematopoietic stem cell transplantation provides the most powerful antileukemic effect in the treatment of acute myelold leukemia. Due to its significant morbidity and mortality, it should be used in first remission patients whose relapse risk is substantial, Reduced intensity transplantation is safer and extends the application of early transplantation to older patients and those with comorbidities. In patients with advanced disease, allotransplantation provides a lower chance for cure, but is often the only curative treatment available. Advances in hisfocompatibility typing and supportive care have improved results of allogeneic transplantation in acute myeloid leukemia.

引用

页码：559 / 568

页数：10

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