Predictors of COVID-19 outcome in Parkinson's disease

被引：61

作者：

Fasano, Alfonso ^{[1
,2
,3
]}

Elia, Antonio E. ^{[4
]}

Dallocchio, Carlo ^{[5
]}

Canesi, Margherita ^{[6
]}

Alimonti, Dario ^{[7
]}

Sorbera, Chiara ^{[8
]}

Alonso-Canovas, Araceli ^{[9
]}

Pezzoli, Gianni ^{[10
]}

机构：

[1] Univ Toronto, Toronto Western Hosp, Div Neurol, UHN,Edmond J Safra Program Parkinsons Dis, Toronto, ON, Canada

[2] Univ Toronto, Toronto Western Hosp, Morton & Gloria Shulman Movement Disorders Ctr, UHN,Div Neurol, Toronto, ON, Canada

[3] Krembil Brain Inst, Toronto, ON, Canada

[4] Fdn IRCCS Ist Neurol C Besta, Movement Disorders Unit, Milan, Italy

[5] ASST Pavia, Neurol Unit, Pavia, Italy

[6] Moriggia Pelascini Hosp, Neurorehabil Dept, Parkinson Ctr, Gravedona Ed Uniti, CO, Italy

[7] ASST Papa Giovanni XXIII Hosp, Dept Neurosci, Neurol Unit, Bergamo, Italy

[8] IRCCS Ctr Neurolesi Bonino Pulejo, Messina, Italy

[9] Hosp Univ Ramon & Cajal, Neurol Dept, Madrid, Spain

[10] Grigioni Fdn Parkinson, Ctr Parkinson, Pini CTO, Milan, Italy

来源：

PARKINSONISM & RELATED DISORDERS | 2020年 / 78卷

关键词：

COVID-19; Dementia; Parkinson's disease; Outcome; CORONAVIRUS; LEVODOPA;

D O I：

10.1016/j.parkreldis.2020.08.012

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Specific pre-existing medical conditions (e.g. hypertension or obesity), advanced age and male sex appear linked to more severe manifestations of SARS Co-V2 infection, thus raising the question of whether Parkinson's disease (PD) poses an increased risk of morbidity and mortality in COVID-19 patients. Methods: In order to describe the outcome of COVID-19 in multi-centre a cohort of PD patients and explore its potential predictors, we gathered the clinical information of 117 community-dwelling patients with COVID-19 followed in 21 tertiary centres in Italy, Iran, Spain, and the UK. Results: Overall mortality was 19.7%, with a significant effect of co-occurrence of dementia, hypertension, and PD duration. Conclusions: The frailty caused by advanced PD poses an increased risk of mortality during COVID-19.

引用

页码：134 / 137

页数：4

共 21 条

[1]

[Anonymous], 2020, J MED VIROL, DOI DOI 10.1002/jmv.25824

[2]

[Anonymous], 2019, MOV DISORD

[3] Outcome of Parkinson's Disease Patients Affected by COVID-19 [J].

Antonini, Angelo ;

Leta, Valentina ;

Teo, James ;

Chaudhuri, K. Ray .

MOVEMENT DISORDERS, 2020, 35 (06) :905-908

[4]

Fasano A., 2020, MOV DISORD

[5] Management of Advanced Therapies in Parkinson's Disease Patients in Times of Humanitarian Crisis: The COVID-19 Experience [J].

Fasano, Alfonso ;

Antonini, Angelo ;

Katzenschlager, Regina ;

Krack, Paul ;

Odin, Per ;

Evans, Andrew H. ;

Foltynie, Thomas ;

Volkmann, Jens ;

Merello, Marcelo .

MOVEMENT DISORDERS CLINICAL PRACTICE, 2020, 7 (04) :361-372

[6] CEREBROSPINAL-FLUID ANTIBODIES TO CORONAVIRUS IN PATIENTS WITH PARKINSONS-DISEASE [J].

FAZZINI, E ;

FLEMING, J ;

FAHN, S .

MOVEMENT DISORDERS, 1992, 7 (02) :153-158

[7] Neurological Complications of Coronavirus Disease (COVID-19): Encephalopathy [J].

Filatov, Asia ;

Sharma, Pamraj ;

Hindi, Fawzi ;

Espinosa, Patricio S. .

CUREUS JOURNAL OF MEDICAL SCIENCE, 2020, 12 (03)

[8] The Coronavirus and the Risks to the Elderly in Long-Term Care [J].

Gardner, William ;

States, David ;

Bagley, Nicholas .

JOURNAL OF AGING & SOCIAL POLICY, 2020, 32 (4-5) :310-315

[9] A SARS-CoV-2 protein interaction map reveals targets for drug repurposing [J].

Gordon, David E. ;

Jang, Gwendolyn M. ;

Bouhaddou, Mehdi ;

Xu, Jiewei ;

Obernier, Kirsten ;

White, Kris M. ;

O'Meara, Matthew J. ;

Rezelj, Veronica V. ;

Guo, Jeffrey Z. ;

Swaney, Danielle L. ;

Tummino, Tia A. ;

Huttenhain, Ruth ;

Kaake, Robyn M. ;

Richards, Alicia L. ;

Tutuncuoglu, Beril ;

Foussard, Helene ;

Batra, Jyoti ;

Haas, Kelsey ;

Modak, Maya ;

Kim, Minkyu ;

Haas, Paige ;

Polacco, Benjamin J. ;

Braberg, Hannes ;

Fabius, Jacqueline M. ;

Eckhardt, Manon ;

Soucheray, Margaret ;

Bennett, Melanie J. ;

Cakir, Merve ;

McGregor, Michael J. ;

Li, Qiongyu ;

Meyer, Bjoern ;

Roesch, Ferdinand ;

Vallet, Thomas ;

Mac Kain, Alice ;

Miorin, Lisa ;

Moreno, Elena ;

Naing, Zun Zar Chi ;

Zhou, Yuan ;

Peng, Shiming ;

Shi, Ying ;

Zhang, Ziyang ;

Shen, Wenqi ;

Kirby, Ilsa T. ;

Melnyk, James E. ;

Chorba, John S. ;

Lou, Kevin ;

Dai, Shizhong A. ;

Barrio-Hernandez, Inigo ;

Memon, Danish ;

Hernandez-Armenta, Claudia .

NATURE, 2020, 583 (7816) :459-+

[10] The Impact of the COVID-19 Pandemic on Parkinson?s Disease: Hidden Sorrows and Emerging Opportunities [J].

Helmich, Rick C. ;

Bloem, Bastiaan R. .

JOURNAL OF PARKINSONS DISEASE, 2020, 10 (02) :351-354

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