Polyacrylamide-coated MCM-48 mesoporous silica spheres: synthesis, characterization and drug delivery study

被引：8

作者：

Ivan Melendez-Ortiz, H. ^{[1
]}

Puente-Urbina, Bertha ^{[2
]}

Ibarra-Vallejo, Erika ^{[3
]}

Garcia-Uriostegui, Lorena ^{[4
]}

Ortega, Alejandra ^{[5
]}

机构：

[1] CONACyT Ctr Invest Quim Aplicada, Blvd Enrique Reyna Hermosillo 140, Saltillo 25294, Coahuila, Mexico

[2] Ctr Invest Quim Aplicada, Blvd Enrique Reyna Hermosillo 140, Saltillo 25294, Coahuila, Mexico

[3] Univ Autonoma Coahuila, Fac Ciencias Quim, Blvd Venustiano Carranza, Saltillo 25000, Coahuila, Mexico

[4] Univ Guadalajara, CONACyT Dept Madera Celulosa & Papel, Carretera Guadalajara Nogales Km 15-5, Zapopan 45110, Jalisco, Mexico

[5] Univ Nacl Autonoma Mexico, Inst Ciencias Nucl, Circuito Exterior S-N, Mexico City 04510, DF, Mexico

来源：

JOURNAL OF POROUS MATERIALS | 2018年 / 25卷 / 03期

关键词：

MCM-48; Hybrid material; Drug delivery; Mesoporous silica; MCM-48-PAAm; CARBON-DIOXIDE ADSORPTION; IN-SITU POLYMERIZATION; PHYSICOCHEMICAL PROPERTIES; HYBRID MATERIALS; NANOPARTICLES; NANOCOMPOSITE; TEMPERATURE; COMPOSITE; FUNCTIONALIZATION; LUMINESCENCE;

D O I：

10.1007/s10934-017-0477-z

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Mesoporous type-MCM-48 silica was grafted with polyacrylamide (PAAm) by using an azo-type initiator. The effect of monomer and initiator concentrations, reaction time, and temperature were evaluated to determine the optimal grafting conditions. Functionalized MCM-48 silicas were characterized by X-ray diffraction (XRD), infrared spectroscopy, thermogravimetric analysis, nitrogen adsorption-desorption analyses, scanning electron microscopy (SEM) and transmission electron microscopy (TEM) which confirmed the grafting process. According to XRD, SEM and TEM results, PAAm-modified MCM-48 silica did not show changes in its morphology and mesostructure by comparing with pristine MCM-48. Also, modified silicas were tested as delivery system using nalidixic acid as drug model. MCM-48-PAAm silicas were able to load more significant amounts of nalidixic acid than the unmodified MCM-48, and showed a sustained delivery behaviour, releasing about 80% of drug.

引用

页码：649 / 656

页数：8

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