Cortical thickness and hippocampal shape in pure vascular mild cognitive impairment and dementia of subcortical type

被引：58

作者：

Kim, H. J. ^{[1
]}

Ye, B. S. ^{[1
]}

Yoon, C. W. ^{[2
]}

Noh, Y. ^{[3
]}

Kim, G. H. ^{[4
]}

Cho, H. ^{[1
,5
]}

Jeon, S. ^{[6
]}

Lee, J. M. ^{[6
]}

Kim, J. -H. ^{[1
,7
]}

Seong, J. -K. ^{[8
]}

Kim, C. -H. ^{[9
]}

Choe, Y. S. ^{[10
]}

Lee, K. H. ^{[10
]}

Kim, S. T. ^{[11
]}

Kim, J. S. ^{[12
]}

Park, S. E. ^{[13
]}

Kim, J. -H. ^{[1
,7
]}

Chin, J. ^{[1
]}

Cho, J. ^{[14
]}

Kim, C. ^{[14
]}

Lee, J. H. ^{[15
]}

Weiner, M. W. ^{[16
]}

Na, D. L. ^{[1
]}

Seo, S. W. ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurol, Seoul 135710, South Korea

[2] Inha Univ, Sch Med, Dept Neurol, Inchon, South Korea

[3] Gachon Univ, Gil Med Ctr, Dept Neurol, Inchon, South Korea

[4] Ewha Womans Univ, Sch Med, Mokdong Hosp, Dept Neurol, Seoul, South Korea

[5] Yonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Neurol, Seoul, South Korea

[6] Hanyang Univ, Dept Biomed Engn, Seoul 133791, South Korea

[7] Korea Univ, Dept Comp & Radio Commun Engn, Seoul, South Korea

[8] Korea Univ, Dept Biomed Engn, Seoul, South Korea

[9] Korea Univ, Seoul, South Korea

[10] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Nucl Med, Seoul 135710, South Korea

[11] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Radiol, Seoul 135710, South Korea

[12] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Nucl Med, Seoul, South Korea

[13] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Adv Inst Hlth Sci & Technol, Seoul 135710, South Korea

[14] Yonsei Univ, Coll Med, Dept Prevent Med, Seoul, South Korea

[15] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Neurol, Seoul, South Korea

[16] Univ Calif San Francisco, Ctr Imaging Neurodegenerat Dis, San Francisco, CA 94143 USA

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2014年 / 21卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

cortical thickness; hippocampal shape; Pittsburgh compound B PET; subcortical vascular dementia; subcortical vascular mild cognitive impairment; ALZHEIMERS-DISEASE; SELECTIVE VULNERABILITY; ATROPHY; PROFILES; FEATURES;

D O I：

10.1111/ene.12376

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and purposeThe progression pattern of brain structural changes in patients with isolated cerebrovascular disease (CVD) remains unclear. To investigate the role of isolated CVD in cognitive impairment patients, patterns of cortical thinning and hippocampal atrophy in pure subcortical vascular mild cognitive impairment (svMCI) and pure subcortical vascular dementia (SVaD) patients were characterized. MethodsForty-five patients with svMCI and 46 patients with SVaD who were negative on Pittsburgh compound B (PiB) positron emission tomography imaging and 75 individuals with normal cognition (NC) were recruited. ResultsCompared with NC, patients with PiB(-) svMCI exhibited frontal, language and retrieval type memory dysfunctions, which in patients with PiB(-) SVaD were further impaired and accompanied by visuospatial and recognition memory dysfunctions. Compared with NC, patients with PiB(-) svMCI exhibited cortical thinning in the frontal, perisylvian, basal temporal and posterior cingulate regions. This atrophy was more prominent and extended further toward the lateral parietal and medial temporal regions in patients with PiB(-) SVaD. Compared with NC subjects, patients with PiB(-) svMCI exhibited hippocampal shape deformities in the lateral body, whilst patients with PiB(-) SVaD exhibited additional deformities within the lateral head and inferior body. ConclusionsOur findings suggest that patients with CVD in the absence of Alzheimer's disease pathology can be demented, showing cognitive impairment in multiple domains, which is consistent with the topography of cortical thinning and hippocampal shape deformity.

引用

页码：744 / 751

页数：8

共 27 条

[1] Frequent Amyloid Deposition Without Significant Cognitive Impairment Among the Elderly [J].

Aizenstein, Howard Jay ;

Nebes, Robert D. ;

Saxton, Judith A. ;

Price, Julie C. ;

Mathis, Chester A. ;

Tsopelas, Nicholas D. ;

Ziolko, Scott K. ;

James, Jeffrey A. ;

Snitz, Beth E. ;

Houck, Patricia R. ;

Bi, Wenzhu ;

Cohen, Ann D. ;

Lopresti, Brian J. ;

DeKosky, Steven T. ;

Halligan, Edythe M. ;

Klunk, William E. .

ARCHIVES OF NEUROLOGY, 2008, 65 (11) :1509-1517

[2] Conversion of mild cognitive impairment to Alzheimer disease predicted by hippocampal atrophy maps [J].

Apostolova, Liana G. ;

Dutton, Rebecca A. ;

Dinov, Ivo D. ;

Hayashi, Kiralee M. ;

Toga, Arthur W. ;

Cummings, Jeffrey L. ;

Thompson, Paul M. .

ARCHIVES OF NEUROLOGY, 2006, 63 (05) :693-699

[3] Vascular and Alzheimer's disease markers independently predict brain atrophy rate in Alzheimer's Disease Neuroimaging Initiative controls [J].

Barnes, Josephine ;

Carmichael, Owen T. ;

Leung, Kelvin K. ;

Schwarz, Christopher ;

Ridgway, Gerard R. ;

Bartlett, Jonathan W. ;

Malone, Ian B. ;

Schott, Jonathan M. ;

Rossor, Martin N. ;

Biessels, Geert Jan ;

DeCarli, Charlie ;

Fox, Nick C. .

NEUROBIOLOGY OF AGING, 2013, 34 (08) :1996-2002

[4] Functional Impairment in Elderly Patients With Mild Cognitive Impairment and Mild Alzheimer Disease [J].

Brown, Patrick J. ;

Devanand, D. P. ;

Liu, Xinhua ;

Caccappolo, Elise .

ARCHIVES OF GENERAL PSYCHIATRY, 2011, 68 (06) :617-626

[5]

CERVOSNAVARRO J, 1991, CRIT REV NEUROBIOL, V6, P149

[6] VASCULAR SUBCORTICAL DEMENTIAS - CLINICAL ASPECTS [J].

CUMMINGS, JL .

DEMENTIA, 1994, 5 (3-4) :177-180

[7]

de Mendonça A, 2005, EUR J NEUROL, V12, P125

[8] PATHOLOGICAL CORRELATES OF INCIDENTAL MRI WHITE-MATTER SIGNAL HYPERINTENSITIES [J].

FAZEKAS, F ;

KLEINERT, R ;

OFFENBACHER, H ;

SCHMIDT, R ;

KLEINERT, G ;

PAYER, F ;

RADNER, H ;

LECHNER, H .

NEUROLOGY, 1993, 43 (09) :1683-1689

[9] Mild cognitive impairment with subcortical vascular features - Clinical characteristics and outcome [J].

Frisoni, GB ;

Galluzzi, S ;

Bresciani, L ;

Zanetti, O ;

Geroldi, C .

JOURNAL OF NEUROLOGY, 2002, 249 (10) :1423-1432

[10] Multidimensional classification of hippocampal shape features discriminates Alzheimer's disease and mild cognitive impairment from normal aging [J].

Gerardin, Emilie ;

Chetelat, Gael ;

Chupin, Marie ;

Cuingnet, Remi ;

Desgranges, Beatrice ;

Kim, Ho-Sung ;

Niethammer, Marc ;

Dubois, Bruno ;

Lehericy, Stephane ;

Garnero, Line ;

Eustache, Francis ;

Colliot, Olivier .

NEUROIMAGE, 2009, 47 (04) :1476-1486

← 1 2 3 →