Cognitive impairment and quality of life in patients with myotonic dystrophy type 1

被引：28

作者：

Fujino, Haruo ^{[1
,2
]}

Shingaki, Honoka ^{[2
]}

Suwazono, Shugo ^{[3
]}

Ueda, Yukihiko ^{[4
]}

Wada, Chizu ^{[5
]}

Nakayama, Takahiro ^{[6
]}

Takahashi, Masanori P. ^{[7
,8
]}

Imura, Osamu ^{[2
]}

Matsumura, Tsuyoshi ^{[9
]}

机构：

[1] Oita Univ, Dept Special Needs Educ, 700 Dannoharu, Oita 8701192, Japan

[2] Osaka Univ, Grad Sch Human Sci, Osaka, Japan

[3] Natl Hosp Org Okinawa Hosp, Dept Neurol, Ginowan, Okinawa, Japan

[4] Okinawa Int Univ, Ginowan, Okinawa, Japan

[5] Natl Hosp Org Akita Natl Hosp, Dept Neurol, Yurihonjo, Japan

[6] Yokohama Rosai Hosp, Dept Neurol, Yokohama, Kanagawa, Japan

[7] Osaka Univ, Grad Sch Med, Dept Funct Diagnost Sci, Osaka, Japan

[8] Osaka Univ, Grad Sch Med, Dept Neurol, Osaka, Japan

[9] Natl Hosp Org Toneyama Natl Hosp, Dept Neurol, Osaka, Japan

来源：

MUSCLE & NERVE | 2018年 / 57卷 / 05期

关键词：

central nervous system; cognitive deficit; depression; fatigue; myotonic dystrophy type 1; quality of life; FALSE DISCOVERY RATE; JAPANESE VERSION; OUTCOME MEASURES; HEALTH; FATIGUE; DISEASE; SEVERITY; ADULTS; QUESTIONNAIRE; PERSONALITY;

D O I：

10.1002/mus.26022

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

IntroductionThis study sought to clarify whether specific cognitive abilities are impaired in patients with myotonic dystrophy type 1 (DM1) as well as to investigate the relationships among quality of life (QoL), cognitive function, and psychological factors. MethodsSixty patients with DM1 were evaluated on cognitive functioning (abstract reasoning, attention/working memory, executive function, processing speed, and visuoconstructive ability), apathy, depression, excessive daytime sleepiness, fatigue, and QoL. QoL was assessed by 2 domains of the Muscular Dystrophy Quality of Life Scale (Psychosocial Relationships and Physical Functioning and Health). ResultsMore than half of the patients exhibited cognitive impairment in attention/working memory, executive function, processing speed, and visuoconstructive ability. The Psychosocial Relationships factor was associated with processing speed, attention/working memory, and apathy, whereas depression and fatigue were associated with 2 QoL domains. DiscussionOur study identified specific cognitive impairments in DM1. Specific cognitive functions and psychological factors may be potential contributors to QoL. Muscle Nerve57: 742-748, 2018

引用

页码：742 / 748

页数：7

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