Noninvasive positive pressure ventilation is required following extubation at the pulmonary infection control window: a prospective observational study

被引:8
作者
Luo, Zujin [1 ,2 ]
Zhan, Qingyuan [1 ]
Wang, Chen [3 ]
机构
[1] Capital Med Univ, Beijing Key Lab Resp & Pulm Circulat, Beijing Inst Resp Med, Dept Resp & Crit Care Med,Beijing Chao Yang Hosp, Beijing, Peoples R China
[2] Capital Med Univ, Beijing Anzhen Hosp, Emergency Intens Care Unit, Beijing, Peoples R China
[3] Beijing Hosp, Beijing Key Lab Resp & Pulm Circulat, Beijing Inst Resp Med, Minist Hlth, Beijing 100730, Peoples R China
关键词
noninvasive positive pressure ventilation; positive pressure respiration; pulmonary disease; chronic obstructive; pulmonary infection control window; respiratory distress after extubation; spontaneous breathing trial; ventilator weaning; RECEIVING MECHANICAL VENTILATION; CRITICALLY-ILL PATIENTS; NOSOCOMIAL PNEUMONIA; RESPIRATORY-FAILURE; SUPPORT VENTILATION; ACUTE EXACERBATIONS; BREATHING TRIAL; RISK; DISEASE;
D O I
10.1111/crj.12078
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Introduction: Timely extubation and sequential invasive to noninvasive positive pressure ventilation (NPPV) at the pulmonary infection control (PIC) window is beneficial for patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). However, it remains unclear whether patients can breathe independently at the PIC window and if NPPV is indeed necessary after extubation. Objectives: To assess whether AECOPD patients can breathe independently at the PIC window and thus whether NPPV is necessary after extubation. Methods: We performed a prospective observational study at a university hospital during a 9-month period. We used the spontaneous breathing trial (SBT) to assess whether each patient could breathe independently at the PIC window, then performed extubation. Patients who passed the SBT received venturi oxygen therapy only, whereas those that failed received NPPV. However, if the former showed respiratory distress, they too received NPPV. The primary outcome variables were SBT pass/fail, the demand for NPPV and rate of reintubation within 72 h following extubation. Results: In all, 23 patients were enrolled, 15 (65%) of which passed the SBT. Of these, 12 (80%) developed respiratory distress after extubation and required NPPV (one of whom required reintubation). Of the eight patients that failed, one received reintubation after NPPV. The reintubation rates within 72 h following extubation of SBT-pass (7%) and SBT-fail (13%) patients were comparable. Conclusion: Our results provide experimental evidence that most AECOPD patients can breathe independently at the PIC window, but nonetheless develop respiratory distress and thus require NPPV following extubation.
引用
收藏
页码:338 / 349
页数:12
相关论文
共 41 条
[1]   PHYSIOLOGICAL-EFFECTS OF POSITIVE END-EXPIRATORY PRESSURE AND MASK PRESSURE SUPPORT DURING EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY-DISEASE [J].
APPENDINI, L ;
PATESSIO, A ;
ZANABONI, S ;
CARONE, M ;
GUKOV, B ;
DONNER, CF ;
ROSSI, A .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1994, 149 (05) :1069-1076
[2]   Mortality rate attributable to ventilator-associated nosocomial pneumonia in an adult intensive care unit: A prospective case-control study [J].
Bercault, N ;
Boulain, T .
CRITICAL CARE MEDICINE, 2001, 29 (12) :2303-2309
[3]   Weaning from mechanical ventilation [J].
Boles, J-M. ;
Bion, J. ;
Connors, A. ;
Herridge, M. ;
Marsh, B. ;
Melot, C. ;
Pearl, R. ;
Silverman, H. ;
Stanchina, M. ;
Vieillard-Baron, A. ;
Welte, T. .
EUROPEAN RESPIRATORY JOURNAL, 2007, 29 (05) :1033-1056
[4]   RANDOMIZED CONTROLLED TRIAL OF NASAL VENTILATION IN ACUTE VENTILATORY FAILURE DUE TO CHRONIC OBSTRUCTIVE AIRWAYS DISEASE [J].
BOTT, J ;
CARROLL, MP ;
CONWAY, JH ;
KEILTY, SEJ ;
WARD, EM ;
BROWN, AM ;
PAUL, EA ;
ELLIOTT, MW ;
GODFREY, RC ;
WEDZICHA, JA ;
MOXHAM, J .
LANCET, 1993, 341 (8860) :1555-1557
[5]   COMPARISON OF 3 METHODS OF GRADUAL WITHDRAWAL FROM VENTILATORY SUPPORT DURING WEANING FROM MECHANICAL VENTILATION [J].
BROCHARD, L ;
RAUSS, A ;
BENITO, S ;
CONTI, G ;
MANCEBO, J ;
REKIK, N ;
GASPARETTO, A ;
LEMAIRE, F .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1994, 150 (04) :896-903
[6]   NONINVASIVE VENTILATION FOR ACUTE EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY-DISEASE [J].
BROCHARD, L ;
MANCEBO, J ;
WYSOCKI, M ;
LOFASO, F ;
CONTI, G ;
RAUSS, A ;
SIMONNEAU, G ;
BENITO, S ;
GASPARETTO, A ;
LEMAIRE, F ;
ISABEY, D ;
HARF, A .
NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (13) :817-822
[7]   Use of non-invasive ventilation to wean critically ill adults off invasive ventilation: meta-analysis and systematic review [J].
Burns, Karen E. A. ;
Adhikari, Neill K. J. ;
Keenan, Sean P. ;
Meade, Maureen .
BMJ-BRITISH MEDICAL JOURNAL, 2009, 338 :1305-1308
[8]   Comparison of noninvasive positive pressure ventilation with standard medical therapy in hypercapnic acute respiratory failure [J].
Çelikel, T ;
Sungur, M ;
Ceyhan, B ;
Karakurt, S .
CHEST, 1998, 114 (06) :1636-1642
[9]   Ventilator-associated pneumonia [J].
Chastre, J ;
Fagon, JY .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2002, 165 (07) :867-903
[10]  
Chen W, 2005, CHINESE MED J-PEKING, V118, P2034