Design, synthesis and antitumor activity in vitro of a series of 3-arylcoumarins

被引：4

作者：

Liu Zhi-hui ^{[1
]}

Li De-jun ^{[2
]}

Jiang Dan ^{[3
]}

Xiao Chuan ^{[2
]}

Song Zhi-guang ^{[2
]}

Jin Ying-hua ^{[3
]}

机构：

[1] Jilin Univ, Coll Chem, Sch Stomatol, Dept Prosthodont, Changchun 130021, Peoples R China

[2] Jilin Univ, Coll Chem, Dept Organ Chem, Changchun 130021, Peoples R China

[3] Jilin Univ, Minist Educ, Key Lab Mol Enzymol & Engn, Changchun 130012, Peoples R China

来源：

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES | 2013年 / 29卷 / 06期

基金：

中国国家自然科学基金;

关键词：

3-Arylcoumarin; Antitumor activity; Structure modification; BIOLOGICAL-ACTIVITY; INHIBITORY-ACTIVITY; DERIVATIVES; COUMARIN; APOPTOSIS; ANALOGS; POTENT; CELLS;

D O I：

10.1007/s40242-013-3107-6

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new series of 7-substituted 3-arylcoumarins was designed, synthesized and evaluated as novel antitumor agents in vitro. It was found that several compounds of them exhibit activity in vitro against SK-HEP-1(hepatocellu- lar carcinoma), HepG2(hepatocellular carcinoma) and SGC7901(gastric carcinoma) cell lines to some extent. Moreover, compounds 5a, 5b, 6a and 6b have better activity against HeLa(cervical carcinoma) cell and their half maximal inhibitory concentration(IC50, mu mol/L).

引用

页码：1125 / 1128

页数：4

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