Application of Salivary Biomarkers in the Diagnosis of Fibromyalgia

被引：10

作者：

Illescas-Montes, Rebeca ^{[1
,2
]}

Costela-Ruiz, Victor J. ^{[1
,2
]}

Melguizo-Rodriguez, Lucia ^{[1
,2
]}

De Luna-Bertos, Elvira ^{[1
,2
]}

Ruiz, Concepcion ^{[1
,2
,3
]}

Ramos-Torrecillas, Javier ^{[1
,2
]}

机构：

[1] Univ Granada, Dept Nursing, Biomed Grp BIO277, Fac Hlth Sci, Granada 18016, Spain

[2] Univ Granada, Inst Invest Biosanit, Ibs Granada, Granada 18016, Spain

[3] Univ Granada, Inst Neurosci, Granada 18016, Spain

来源：

DIAGNOSTICS | 2021年 / 11卷 / 01期

关键词：

fibromyalgia; saliva; biomarkers; diagnosis;

D O I：

10.3390/diagnostics11010063

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Fibromyalgia (FM) is a highly prevalent syndrome that impairs the quality of life of the patients; however, its diagnosis is complex and mainly centered on pain symptoms. The study of salivary biomarkers has proven highly useful for the diagnosis and prognosis of numerous diseases. The objective of this review was to gather published data on the utilization of salivary biomarkers to facilitate and complement the diagnosis of FM. Salivary biomarkers used in FM diagnosis include cortisol; calgranulin; and the enzymes alpha-amylase, transaldolase, and phosphoglycerate mutase. Increased serum levels of C-reactive protein, cytokines interleukin 1-beta, interleukin 6, interleukin 8, interleukin 10, interleukin 17, tumor necrosis factor alpha, and various chemokines may serve as salivary biomarkers, given observations of their increased serum levels in patients with FM. Further research is warranted to study in depth the role and performance of biomarkers currently used in FM diagnosis/prognosis and to identify novel salivary biomarkers for this disease.

引用

页数：14

共 130 条

[1] IL-17: overview and role in oral immunity and microbiome [J].