Circulating adiponectin as a biomarker in renal cell carcinoma: a systematic review and meta-analysis

被引：6
作者：
Yap, Ning Yi [1 ]
Yap, Foo Ngan [2 ]
Perumal, Komathi [1 ]
Rajandram, Retnagowri [1 ]
机构：
[1] Univ Malaya, Dept Surg, Fac Med, Kuala Lumpur 50605, Malaysia
[2] Univ Kuala Lumpur, Community Based Dept, Royal Coll Med Perak, Perak, Malaysia
来源：
BIOMARKERS | 2019年 / 24卷 / 06期
关键词：
Adiponectin; adipokine; circulating; obesity; renal cell carcinoma; CANCER-RISK; OBESITY; LEPTIN; LEVEL; SIZE;
D O I：
10.1080/1354750X.2019.1634763
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Context: Metabolic imbalance in renal cell carcinoma (RCC) can lead to abnormal adiponectin levels. Objective: To evaluate circulating adiponectin as a detection or predictive marker for RCC. Methods: A comprehensive literature search and meta-analysis was performed on studies reporting circulating adiponectin levels and RCC. The meta-analysis was performed using RevMan. Results: Seven studies compared the circulating adiponection levels between RCC cases and controls. Adiponectin level was significantly lower in RCC cases compared to controls at pre-diagnosis and pre-operative time-points. RCC stage, grade and subtype did not affect adiponectin levels. Conclusion: Low circulating adiponectin could be a predictive or risk factor for RCC.
引用
收藏
页码：607 / 614
页数：8
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