Eight years experience of local prostate cancer treatment with permanent I125 seed brachytherapy - Morbidity and outcome results

Background and purpose: There are only a limited number of reports of treatment of prostate cancer with permanent Prostate seed I-125 brachytherapy (PPB) in Europe. We describe results from one Finnish institution having treated 444 patients with a follow-up of eight years. Material and methods: Morbidity was evaluated by International Prostate Symptom Score and international Index of Erectile Function questionnaires. Urine flow, residual urine Volume and the PSA values were measured pre-treatment and during follow-up. Any additional treatments were recorded. Results: PPB was well tolerated. Median IPSS increased from 8 at baseline to IS at three months post-therapy and returned to baseline score within 12 months. Median urine flow decreased from 15.2 ml/s at baseline to 10.2 ml/s at three months and returned to baseline value within two years. Acute urinary retention, potency preservation and severe proctitis were observed in 11%, 86% and 2% of patients, respectively. The PSA bounce was observed in 13% and PSA nadir <= 0.5 mu g/l was reached by 81% of patients. Disease-free survival (DFS) was 90.2%. In the Cox regression analysis, the independent predictors of DFS were risk group and PSA nadir <= 0.5 mu g/l (p < 0.0001 for both). PC-specific Survival Was 98.5% and overall survival was 94.6%. Conclusions: Our results are in concordance and comparable with other reports on PPB. (C) 2009 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 91 (2009) 213-216