Emergence of a novel subclade of influenza A(H3N2) virus in London, December 2016 to January 2017

被引：25

作者：

Harvala, H. ^{[1
,2
]}

Frampton, D. ^{[2
]}

Grant, P. ^{[1
]}

Raffle, J. ^{[2
]}

Ferns, R. B. ^{[2
,3
]}

Kozlakidis, Z. ^{[2
]}

Kellam, P. ^{[4
]}

Pillay, D. ^{[2
]}

Hayward, A. ^{[5
]}

Nastouli, E. ^{[1
,3
,6
]}

机构：

[1] Univ Coll London Hosp NHS Fdn Trust, Dept Clin Virol, London, England

[2] UCL, Dept Infect & Immun, London, England

[3] NIHR UCLH UCL Biomed Res Ctr, London, England

[4] Imperial Coll, Fac Med, Dept Med, London, England

[5] Farr Inst Hlth Informat Res, Dept Infect Dis Informat, London, England

[6] UCL GOS Inst Child Hlth, Dept Populat Policy & Practice, London, England

来源：

EUROSURVEILLANCE | 2017年 / 22卷 / 08期

基金：

英国惠康基金;

关键词：

SITES;

D O I：

10.2807/1560-7917.ES.2017.22.8.30466

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We report the molecular investigations of a large influenza A(H3N2) outbreak, in a season characterised by sharp increase in influenza admissions since December 2016. Analysis of haemagglutinin (HA) sequences demonstrated co-circulation of multiple clades (3C.3a, 3C.2a and 3C.2a1). Most variants fell into a novel subclade (proposed as 3C.2a2); they possessed four unique amino acid substitutions in the HA protein and loss of a potential glycosylation site. These changes potentially modify the H3N2 strain antigenicity. © 2017, European Centre for Disease Prevention and Control (ECDC). All Rights Reserved.

引用

页码：7 / 12

页数：6

共 14 条

[1]

[Anonymous], 2017, SAS INFL 2016 2017

[2]

European Centre for Disease Prevention and Control, 2016, INFL VIR CHAR SUMM E

[3]

European Centre for Disease Prevention and Control, 2015, INFL VIR CHAR SUMM E

[4]

European Centre for Disease prevention and Control (ECDC), 2017, RISK ASS SEAS INFL E

[5] IVA: accurate de novo assembly of RNA virus genomes [J].

Hunt, Martin ;

Gall, Astrid ;

Ong, Swee Hoe ;

Brener, Jacqui ;

Ferns, Bridget ;

Goulder, Philip ;

Nastouli, Eleni ;

Keane, Jacqueline A. ;

Kellam, Paul ;

Otto, Thomas D. .

BIOINFORMATICS, 2015, 31 (14) :2374-2376

[6] Evidence for N-Glycan Shielding of Antigenic Sites during Evolution of Human Influenza A Virus Hemagglutinin [J].

Kobayashi, Yuki ;

Suzuki, Yoshiyuki .

JOURNAL OF VIROLOGY, 2012, 86 (07) :3446-3451

[7] Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution [J].

Koel, Bjorn F. ;

Burke, David F. ;

Bestebroer, Theo M. ;

van der Vliet, Stefan ;

Zondag, Gerben C. M. ;

Vervaet, Gaby ;

Skepner, Eugene ;

Lewis, Nicola S. ;

Spronken, Monique I. J. ;

Russell, Colin A. ;

Eropkin, Mikhail Y. ;

Hurt, Aeron C. ;

Barr, Ian G. ;

de Jong, Jan C. ;

Rimmelzwaan, Guus F. ;

Osterhaus, Albert D. M. E. ;

Fouchier, Ron A. M. ;

Smith, Derek J. .

SCIENCE, 2013, 342 (6161) :976-979

[8]

National Institute for Health and Welfare. Finland, 2017, INFL LEV NYT ROK EHT

[9] Haemagglutinin mutations and glycosylation changes shaped the 2012/13 influenza A(H3N2) epidemic, Houston, Texas [J].

Stucker, K. M. ;

Schobel, S. A. ;

Olsen, R. J. ;

Hodges, H. L. ;

Lin, X. ;

Halpin, R. A. ;

Fedorova, N. ;

Stockwell, T. B. ;

Tovchigrechko, A. ;

Das, S. R. ;

Wentworth, D. E. ;

Musser, J. M. .

EUROSURVEILLANCE, 2015, 20 (18) :20-34

[10]

Tamura K, 2013, MOL BIOL EVOL, V30, P2725, DOI [10.1093/molbev/mst197, 10.1093/molbev/msr121]

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