Cucurbitacins from Trichosanthes kirilowii as the inhibitory components on tyrosinase activity and melanin synthesis of B16/F10 melanoma cells

被引：60
作者：
Oh, H
Mun, YJ
Im, SJ
Lee, SY
Song, HJ
Lee, HS
Woo, WH [1 ]
机构：
[1] Wonkwang Univ, Profess Grad Sch Oriental Med, Iksan 570749, Chonbuk, South Korea
[2] Wonkwang Univ, Coll Oriental Med, Iksan 570749, Chonbuk, South Korea
来源：
PLANTA MEDICA | 2002年 / 68卷 / 09期
关键词：
D O I：
10.1055/s-2002-34418
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Cucurbitacins 1 and 2 were isolated from the root of Trichosanthes kirilowii by tyrosinase inhibitory activity-guided fractionation. Spectroscopic analysis revealed that compounds 1 and 2 were cucurbitacin D and 23,24-dihydro-cucurbitacin D, respectively. Compounds 1 and 2 effectively inhibited the activity of tyrosinase (IC50 = 0.18 muM and 6.7 muM, respectively), and the synthesis of melanin (IC50 = 0.16 muM and 7.5 muM, respectively) in B16/F10 melanoma cells.
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收藏
页码：832 / 833
页数：2
相关论文
共 14 条
[1]   Inhibitors of mammalian melanocyte tyrosinase:: In vitro comparisons of alkyl esters of gentisic acid with other putative inhibitors [J].
Curto, EV ;
Kwong, C ;
Hermersdörfer, H ;
Glatt, H ;
Santis, C ;
Virador, V ;
Hearing, VJ ;
Dooley, TP .
BIOCHEMICAL PHARMACOLOGY, 1999, 57 (06) :663-672
[2]   CUCURBITACINS - DIFFERENTIAL CYTOTOXICITY, DEREPLICATION AND FIRST ISOLATION FROM GONYSTYLUS-KEITHII [J].
FULLER, RW ;
CARDELLINA, JH ;
CRAGG, GM ;
BOYD, MR .
JOURNAL OF NATURAL PRODUCTS, 1994, 57 (10) :1442-1445
[3]  
HOSOI J, 1985, CANCER RES, V45, P1474
[4]   ROLE OF TYROSINASE AS THE DETERMINANT OF PIGMENTATION IN CULTURED HUMAN MELANOCYTES [J].
IOZUMI, K ;
HOGANSON, GE ;
PENNELLA, R ;
EVERETT, MA ;
FULLER, BB .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1993, 100 (06) :806-811
[5]   Tyrosinase inhibitors from Artocarpus gomezianus [J].
Likhitwitayawuid, K ;
Sritularak, B ;
De-Eknamkul, W .
PLANTA MEDICA, 2000, 66 (03) :275-277
[6]   Mechanisms of melanogenesis inhibition by tumor necrosis factor-α in B16/F10 mouse melanoma cells [J].
Martínez-Esparza, M ;
Jiménez-Cervantes, C ;
Solano, F ;
Lozano, JA ;
García-Borrón, JC .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1998, 255 (01) :139-146
[7]   RAPID COLORIMETRIC ASSAY FOR CELLULAR GROWTH AND SURVIVAL - APPLICATION TO PROLIFERATION AND CYTO-TOXICITY ASSAYS [J].
MOSMANN, T .
JOURNAL OF IMMUNOLOGICAL METHODS, 1983, 65 (1-2) :55-63
[8]   CUCURBITACINS, CELL-ADHESION INHIBITORS FROM CONOBEA SCOPARIOIDES [J].
MUSZA, LL ;
SPEIGHT, P ;
MCELHINEY, S ;
BARROW, CJ ;
GILLUM, AM ;
COOPER, R ;
KILLAR, LM .
JOURNAL OF NATURAL PRODUCTS-LLOYDIA, 1994, 57 (11) :1498-1502
[9]   Inhibition of tyrosinase by green tea components [J].
No, JK ;
Soung, DY ;
Kim, YJ ;
Shim, KH ;
Jun, YS ;
Rhee, SH ;
Yokozawa, T ;
Chung, HY .
LIFE SCIENCES, 1999, 65 (21) :PL241-PL246
[10]   Anti-inflammatory effects of the products from Wilbrandia ebracteata on carrageenan-induced pleurisy in mice [J].
Peters, RR ;
Saleh, TF ;
Lora, M ;
Patry, C ;
de Brum-Fernandes, AJ ;
Farias, MR ;
Ribeiro-do-Valle, RM .
LIFE SCIENCES, 1999, 64 (26) :2429-2437
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