A Nomogram for Prediction of Overall Survival in Patients with Node-negative Gallbladder Cancer

被引:28
作者
Chen, Mingyu [1 ,2 ,3 ]
Cao, Jiasheng [1 ]
Zhang, Bin [1 ]
Pan, Long [1 ]
Cai, Xiujun [1 ,2 ,3 ]
机构
[1] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Gen Surg, Hangzhou 310016, Zhejiang, Peoples R China
[2] Zhejiang Univ, Sir Run Run Shaw Hosp, Key Lab Endoscop Tech Res Zhejiang Prov, Hangzhou 310016, Zhejiang, Peoples R China
[3] Engn Res Ctr Cognit Healthcare Zhejiang Prov, Tianjin 310003, Zhejiang, Peoples R China
关键词
gallbladder cancer; nomogram; node-negative; overall survival; PAPILLARY MUCINOUS NEOPLASMS; PROSTATE-CANCER; BILIARY-TRACT; VALIDATION; DISSECTION; RECURRENCE; MALIGNANCY; CARCINOMA; BENEFIT; IMPACT;
D O I
10.7150/jca.30046
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background & Aims: According to the stage of tumor, it's hard suitable to predict the prognosis for gallbladder cancer, especially for node-negative gallbladder cancer. Therefore, we aimed to create a nomogram based on demographic and clinicopathologic characteristics to estimate individualized potential impacts on postoperative overall survival. Methods: 789 patients with node-negative gallbladder cancer were selected from the Surveillance, Epidemiology, and End Results and randomly divided into training and internal validation group. Univariate and multivariate survival analysis were used to identify prognostic factors. The nomogram was constructed using Cox proportional hazards models. We evaluated the performance of the nomogram with Harrell's concordance index and calibration curve. The nomogram was externally validated in 115 patients with node-negative gallbladder cancer from the Sir Run Run Shaw hospital. Results: The nomogram for overall survival was built on the basis of five independent factors, such as age, sex, histology, T-stage, and number of examined lymph nodes. The C-index of nomogram for overall survival in the internal and external validation group was up to 0.724 and 0.716, respectively. Both of those calibration curves showed good agreement between predicted and observed outcomes in the 1-, 3-, 5-year overall survival. Compared to the 7th edition AJCC stage, the nomogram had a better difference in predicting overall survival, even could further classify patients into four risk subgroups in each stage. Conclusion: This nomogram can be used as a decision model to predict the outcomes of postoperative overall survival for node-negative gallbladder cancer, and may give useful guidance to clinicians for next treatment.
引用
收藏
页码:3246 / 3252
页数:7
相关论文
共 31 条
[1]  
[Anonymous], ONCOLOGY
[2]  
[Anonymous], 2002, ONCOLOGY WILLISTON P
[3]   Locally advanced gallbladder cancer: Which patients benefit from resection? [J].
Birnbaum, D. J. ;
Vigano, L. ;
Ferrero, A. ;
Langella, S. ;
Russolillo, N. ;
Capussotti, L. .
EJSO, 2014, 40 (08) :1008-1015
[4]   Nomogram Predicting Prostate Cancer-specific Mortality for Men with Biochemical Recurrence After Radical Prostatectomy [J].
Brockman, John A. ;
Alanee, Shaheen ;
Vickers, Andrew J. ;
Scardino, Peter T. ;
Wood, David P. ;
Kibel, Adam S. ;
Lin, Daniel W. ;
Bianco, Fernando J., Jr. ;
Rabah, Danny M. ;
Klein, Eric A. ;
Ciezki, Jay P. ;
Gao, Tianming ;
Kattan, Michael W. ;
Stephenson, Andrew J. .
EUROPEAN UROLOGY, 2015, 67 (06) :1160-1167
[5]   Development of a nomogram combining clinical staging with 18F-FDG PET/CT image features in non-small-cell lung cancer stage I-III [J].
Desseroit, Marie-Charlotte ;
Visvikis, Dimitris ;
Tixier, Florent ;
Majdoub, Mohamed ;
Perdrisot, Remy ;
Guillevin, Remy ;
Le Rest, Catherine Cheze ;
Hatt, Mathieu .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2016, 43 (08) :1477-1485
[6]   Nomograms for preoperative prediction of axillary nodal status in breast cancer [J].
Dihge, L. ;
Bendahl, P. -O. ;
Ryden, L. .
BRITISH JOURNAL OF SURGERY, 2017, 104 (11) :1494-1505
[7]   Validation of Six Nomograms for Predicting Non-sentinel Lymph Node Metastases in a Dutch Breast Cancer Population [J].
Dingemans, Siem A. ;
de Rooij, Peter D. ;
de Vries, Roos M. van der Vuurst ;
Budel, Leo M. ;
Contant, Caroline M. ;
van der Pool, Anne E. M. .
ANNALS OF SURGICAL ONCOLOGY, 2016, 23 (02) :477-481
[8]  
Donohue JH, 1998, CANCER, V83, P2618, DOI 10.1002/(SICI)1097-0142(19981215)83:12<2618::AID-CNCR29>3.0.CO
[9]  
2-H
[10]   Impact of the number of examined lymph nodes on outcomes in patients with lymph node-negative gallbladder carcinoma [J].
Fan, Dong-Xu ;
Xu, Rong-Wei ;
Li, Yong-Cheng ;
Zhao, Bing-Qing ;
Sun, Ming-Yu .
WORLD JOURNAL OF GASTROENTEROLOGY, 2018, 24 (26) :2886-2892