Failure of intravenous immunoglobulin (IVIg) therapy in experimental autoimmune neuritis (EAN) of the Lewis rat

被引：21

作者：

Enders, U

Toyka, KV

Hartung, HP

Gold, R

机构：

[1] UNIV WURZBURG, DEPT NEUROL, NEUROIMMUNOL BRANCH, D-97080 WURZBURG, GERMANY

[2] UNIV WURZBURG, CLIN RES GRP MULTIPLE SCLEROSIS, D-97080 WURZBURG, GERMANY

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1997年 / 76卷 / 1-2期

关键词：

immune globulin; neuritis; Guillain-Barre syndrome;

D O I：

10.1016/S0165-5728(97)00039-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Experimental autoimmune neuritis (EAN) is an animal model for Guillain-Barre syndrome (GBS). Intravenous immunoglobulins (IVIg) are an effective treatment for GBS, but their mechanism of action is not well understood. Here we tested whether IVIg treatment, a potent modulator of proinflammatory assaults, reduces inflammation in EAN. The evaluation of IVIg treatment failed to demonstrate a salutary effect in different models of EAN. IVIg appears not to suppress the acute inflammatory insult on the peripheral nerve, but may have beneficial long-term effects not looked for in the present investigation.

引用

页码：112 / 116

页数：5

共 18 条

[1] INTRAVENOUS IMMUNOGLOBULIN TREATMENT OF EXPERIMENTAL T-CELL-MEDIATED AUTOIMMUNE-DISEASE - UP-REGULATION OF T-CELL PROLIFERATION AND DOWN-REGULATION OF TUMOR-NECROSIS-FACTOR-ALPHA SECRETION [J].