Synthesis of Bi- and Tricyclic α,β-Unsaturated Lactams as Potential Michael Acceptors Starting from Heterocyclic Imines

被引：10

作者：

Schulz, Knut ^{[1
]}

Watzke, Martin ^{[1
]}

Johannes, Katharina ^{[1
]}

Ullrich, Pasqual ^{[1
]}

Martens, Juergen ^{[1
]}

机构：

[1] Carl von Ossietzky Univ Oldenburg, Inst Pure & Appl Chem, D-26129 Oldenburg, Germany

来源：

SYNTHESIS-STUTTGART | 2009年 / 04期

关键词：

heterocycles; imines; unsaturated lactams; Michael acceptor; ring-closing metathesis; ANTIPLATELET AGGREGATION CONSTITUENTS; RING-CLOSING METATHESIS; FACILE SYNTHESIS; DELTA-LACTAMS; 1,4-BENZOTHIAZINE; DERIVATIVES; ALKALOIDS; ALCOHOLS; AMIDES; T-477;

D O I：

10.1055/s-0028-1083342

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New alpha,beta-unsaturated valerolactams showing potential as Michael acceptors were synthesized from heterocyclic imines as starting materials. The synthetic procedure is based oil an acid chloride addition in the first step, followed by a modified Hosomi-Sakurai reaction, and a final ring-closing metathesis using a ruthenium catalyst.

引用

页码：665 / 673

页数：9

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