Defining best practices for tissue procurement in immuno-oncology clinical trials: consensus statement from the Society for Immunotherapy of Cancer Surgery Committee

被引：21

作者：

Gastman, Brian ^{[1
]}

Agarwal, Piyush K. ^{[2
]}

Berger, Adam ^{[3
]}

Boland, Genevieve ^{[4
]}

Broderick, Stephen ^{[5
,6
]}

Butterfield, Lisa H. ^{[7
,8
]}

Byrd, David ^{[9
]}

Fecci, Peter E. ^{[10
]}

Ferris, Robert L. ^{[11
,12
,13
]}

Fong, Yuman ^{[14
]}

Goff, Stephanie L. ^{[15
]}

Grabowski, Matthew M. ^{[16
]}

Ito, Fumito ^{[17
]}

Lim, Michael ^{[18
,19
,20
,21
]}

Lotze, Michael T. ^{[22
]}

Mahdi, Haider ^{[23
]}

Malafa, Mokenge ^{[24
]}

Morris, Carol D. ^{[25
]}

Murthy, Pranav ^{[26
]}

Neves, Rogerio, I ^{[27
]}

Odunsi, Adekunle ^{[28
,29
]}

Pai, Sara, I ^{[4
]}

Prabhakaran, Sangeetha ^{[30
]}

Rosenberg, Steven A. ^{[31
]}

Saoud, Ragheed ^{[32
]}

Sethuraman, Jyothi ^{[33
]}

Skitzki, Joseph ^{[34
,35
]}

Slingluff, Craig L. ^{[36
]}

Sondak, Vernon K. ^{[37
]}

Sunwoo, John B. ^{[38
]}

Turcotte, Simon ^{[39
]}

Yeung, Cecilia C. S. ^{[40
]}

Kaufman, Howard L. ^{[4
,41
]}

机构：

[1] Cleveland Clin, Dept Plast Surg, Cleveland, OH 44106 USA

[2] Univ Chicago, Dept Surg, 5841 S Maryland Ave, Chicago, IL 60637 USA

[3] Rutgers Canc Inst New Jersey, Div Surg Oncol, New Brunswick, NJ USA

[4] Massachusetts Gen Hosp, Dept Surg Oncol, Boston, MA 02114 USA

[5] Johns Hopkins Med Sidney Kimmel Comprehens Canc C, Oncol, Baltimore, MD USA

[6] Johns Hopkins Med, Dept Surg, Baltimore, MD USA

[7] Parker Inst Canc Immunotherapy, San Francisco, CA USA

[8] Univ Calif San Francisco, Microbiol & Immunol, San Francisco, CA 94143 USA

[9] Univ Washington, Dept Surg, Seattle, WA 98195 USA

[10] Duke Univ, Sch Med, Dept Neurosurg, Durham, NC USA

[11] Univ Pittsburgh, Dept Otolaryngol, Hillman Canc Ctr, Pittsburgh, PA 15260 USA

[12] Univ Pittsburgh, Dept Immunol, Hillman Canc Ctr, Pittsburgh, PA 15260 USA

[13] Univ Pittsburgh, Hillman Canc Ctr, Dept Radiat Oncol, Pittsburgh, PA USA

[14] City Hope Natl Med Ctr, Dept Surg, 1500 E Duarte Rd, Duarte, CA 91010 USA

[15] NCI, NCI SB, Bethesda, MD 20892 USA

[16] Duke Ctr Brain & Spine Metastasis, Dept Neurosurg, Durham, NC USA

[17] Roswell Pk Comprehens Canc Ctr, Dept Surg Oncol, Ctr Immunotherapy, Buffalo, NY USA

[18] Johns Hopkins Univ, Sch Med, Dept Neurosurg, Baltimore, MD 21205 USA

[19] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA

[20] Johns Hopkins Univ, Sch Med, Dept Radiat Oncol, Baltimore, MD 21205 USA

[21] Johns Hopkins Univ, Sch Med, Dept Otolaryngol, Baltimore, MD 21205 USA

[22] Univ Pittsburgh, Sch Med, Dept Surg, Pittsburgh, PA USA

[23] Cleveland Clin, OBGYN & Womens Hlth Inst, Cleveland, OH 44106 USA

[24] H Lee Moffitt Canc Ctr & Res Inst, Dept Gastrointestinal Oncol, Tampa, FL USA

[25] Johns Hopkins Univ, Div Orthopaed Oncol, Baltimore, MD USA

[26] Univ Pittsburgh, Dept Surg, UPMC Hillman Canc Ctr, Pittsburgh, PA USA

[27] Penn State Canc Inst, Dept Surg, Hershey, PA USA

[28] Roswell Pk Canc Inst, Dept Immunol, Buffalo, NY USA

[29] Roswell Pk Canc Inst, Dept Gynecol Oncol, Buffalo, NY USA

[30] Univ New Mexico, UNM Comprehens Canc Ctr, Dept Surg, Div Surg Oncol, Albuquerque, NM USA

[31] NCI, Surg Branch, Bldg 10, Bethesda, MD 20892 USA

[32] Univ Chicago Hosp, Dept Surg, Chicago, IL 60637 USA

[33] Nurix Therapeut Inc, San Francisco, CA USA

[34] Roswell Pk Comprehens Canc Ctr, Dept Surg Oncol, Buffalo, NY USA

[35] Roswell Pk Comprehens Canc Ctr, Dept Immunol, Buffalo, NY USA

[36] Univ Virginia, Dept Surg, Div Surg Oncol Breast & Melanoma Surg, Charlottesville, VA USA

[37] H Lee Moffitt Canc Ctr & Res Inst, Dept Cutaneous Oncol, Tampa, FL USA

[38] Stanford Univ, Dept Otolaryngol, Sch Med, Stanford, CA USA

[39] Univ Montreal, Surg Dept, Ctr Hosp, Montreal, PQ, Canada

[40] Fred Hutchinson Canc Res Ctr, Dept Pathol, 1124 Columbia St, Seattle, WA 98104 USA

[41] Immuneering Corp, Cambridge, MA 02142 USA

来源：

JOURNAL FOR IMMUNOTHERAPY OF CANCER | 2020年 / 8卷 / 02期

关键词：

biomarkers; tumor; guidelines as topic; review; clinical trials as topic; immunotherapy; NUCLEUS RNA-SEQ; LUNG-CANCER; COLORECTAL-CANCER; OPEN-LABEL; ANTITUMOR-ACTIVITY; ANTIBODY BLOCKADE; NEEDLE-BIOPSY; TUMOR; NIVOLUMAB; DOCETAXEL;

D O I：

10.1136/jitc-2020-001583

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immunotherapy is now a cornerstone for cancer treatment, and much attention has been placed on the identification of prognostic and predictive biomarkers. The success of biomarker development is dependent on accurate and timely collection of biospecimens and high-quality processing, storage and shipping. Tumors are also increasingly used as source material for the generation of therapeutic T cells. There have been few guidelines or consensus statements on how to optimally collect and manage biospecimens and source material being used for immunotherapy and related research. The Society for Immunotherapy of Cancer Surgery Committee has brought together surgical experts from multiple subspecialty disciplines to identify best practices and to provide consensus on how best to access and manage specific tissues for immuno-oncology treatments and clinical investigation. In addition, the committee recommends early integration of surgeons and other interventional physicians with expertise in biospecimen collection, especially in clinical trials, to optimize the quality of tissue and the validity of correlative clinical studies in cancer immunotherapy.

引用

页数：17

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