A Genome-wide Scan for Selective Sweeps in Racing Horses

被引：20

作者：

Moon, Sunjin ^{[1
,2
]}

Lee, Jin Woo ^{[3
]}

Shin, Donghyun ^{[1
,2
]}

Shin, Kwang-Yun ^{[4
]}

Kim, Jun ^{[4
]}

Choi, Ik-Young ^{[5
]}

Kim, Jaemin ^{[6
]}

Kim, Heebal ^{[1
,2
,6
,7
]}

机构：

[1] Seoul Natl Univ, Dept Agr Biotechnol, Seoul 151742, South Korea

[2] Seoul Natl Univ, Res Inst Agr & Life Sci, Seoul 151742, South Korea

[3] KRA, Horse Registry, Gwacheon 427711, South Korea

[4] Inst Livestock Promot, Jeju 690802, South Korea

[5] Seoul Natl Univ, Genome Anal Ctr, Natl Instrumentat & Environm Management NICEM, Seoul 151921, South Korea

[6] Seoul Natl Univ, Interdisciplinary Program Bioinformat, Seoul 151742, South Korea

[7] C&K Genom, Seoul 151742, South Korea

来源：

ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES | 2015年 / 28卷 / 11期

关键词：

Single Nucleotide Polymorphism; Racehorse; Selective Sweep; Quantitative Trait Loci; THOROUGHBRED HORSES; MYOSTATIN GENE; SEQUENCE POLYMORPHISM; ASSOCIATION; MSTN; POPULATION; CATTLE; PERFORMANCE; EXPRESSION; MUTATIONS;

D O I：

10.5713/ajas.14.0696

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Using next-generation sequencing, we conducted a genome-wide scan of selective sweeps associated with selection toward genetic improvement in Thoroughbreds. We investigated potential phenotypic consequence of putative candidate loci by candidate gene association mapping for the finishing time in 240 Thoroughbred horses. We found a significant association with the trait for Ral GApase alpha 2 (RALGAP2) that regulates a variety of cellular processes of signal trafficking. Neighboring genes around RALGAP2 included insulinoma-associated 1 (INSM1), pallid (PLDN), and Ras and Rab interactor 2 (RIN2) genes have similar roles in signal trafficking, suggesting that a co-evolving gene cluster located on the chromosome 22 is under strong artificial selection in racehorses.

引用

页码：1525 / 1531

页数：7

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