Quality by Design Approach for Development of W/O Type Microemulsion-Based Transdermal Systems for Atenolol

被引：6
作者：
Dhingani, Anjali [1 ]
Patel, Jaydeep [1 ]
Garala, Kevin [1 ]
Raval, Mihir [2 ]
Dharamsi, Abhay [3 ]
机构：
[1] Atmiya Inst Pharm, Dept Pharmaceut, Rajkot 360005, Gujarat, India
[2] Saurashtra Univ, Dept Pharmaceut Sci, Rajkot 360005, Gujarat, India
[3] Maliba Pharm Coll, Dept Pharmaceut, Surat, Gujarat, India
来源：
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY | 2014年 / 35卷 / 05期
关键词：
Atenolol; transdermal drug delivery; principal component analysis; D-optimal design; thickening agents; microemulsion; quality by design; IN-VIVO; PART II; DELIVERY; SKIN; OPTIMIZATION; FORMULATION; PERMEATION; COMPONENT; VITRO; GEL;
D O I：
10.1080/01932691.2013.802242
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The objective of the present investigation was to develop microemulsion-based transdermal systems of highly water soluble drug, Atenolol, by quality by design technique. Atenolol-loaded W/O microemulsions were optimized using D-optimal design with concentrations of oil, surfactants mixture, and water as independent variables, which was converted into microemulsion-based gel (MBG). The results of in vitro permeation of the optimized batch of Atenolol-loaded MBG revealed significant increase in permeability parameters as compared to its convention gel. All results suggested suitability of W/O type MEs as carriers for transdermal delivery of highly water soluble drug, Atenolol.
引用
收藏
页码：619 / 640
页数：22
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