Quality by Design Approach for Development of W/O Type Microemulsion-Based Transdermal Systems for Atenolol

被引：6

作者：

Dhingani, Anjali ^{[1
]}

Patel, Jaydeep ^{[1
]}

Garala, Kevin ^{[1
]}

Raval, Mihir ^{[2
]}

Dharamsi, Abhay ^{[3
]}

机构：

[1] Atmiya Inst Pharm, Dept Pharmaceut, Rajkot 360005, Gujarat, India

[2] Saurashtra Univ, Dept Pharmaceut Sci, Rajkot 360005, Gujarat, India

[3] Maliba Pharm Coll, Dept Pharmaceut, Surat, Gujarat, India

来源：

JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY | 2014年 / 35卷 / 05期

关键词：

Atenolol; transdermal drug delivery; principal component analysis; D-optimal design; thickening agents; microemulsion; quality by design; IN-VIVO; PART II; DELIVERY; SKIN; OPTIMIZATION; FORMULATION; PERMEATION; COMPONENT; VITRO; GEL;

D O I：

10.1080/01932691.2013.802242

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The objective of the present investigation was to develop microemulsion-based transdermal systems of highly water soluble drug, Atenolol, by quality by design technique. Atenolol-loaded W/O microemulsions were optimized using D-optimal design with concentrations of oil, surfactants mixture, and water as independent variables, which was converted into microemulsion-based gel (MBG). The results of in vitro permeation of the optimized batch of Atenolol-loaded MBG revealed significant increase in permeability parameters as compared to its convention gel. All results suggested suitability of W/O type MEs as carriers for transdermal delivery of highly water soluble drug, Atenolol.

引用

页码：619 / 640

页数：22

共 44 条

[11] Date AA, 2007, CRIT REV THER DRUG, V24, P547
[12] Derle D. V., 2006, Indian Journal of Pharmaceutical Sciences, V68, P622
[13] Draize JH, 1944, J PHARMACOL EXP THER, V82, P377
[14] Fanun M., 2009, SURFACTANT SCI SERIE
[15] Investigating the evolution of the phase behavior of AOT-based w/o microemulsions in dodecane as a function of droplet volume fraction
Ganguly, R.
Choudhury, N.
[J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2012, 372 : 45 - 51
[16] Enhanced encapsulation of metoprolol tartrate with carbon nanotubes as adsorbent
Garala K.
Patel J.
Patel A.
Dharamsi A.
[J]. Applied Nanoscience, 2011, 1 (4) : 219 - 230
[17] Transdermal skin delivery:: Predictions for humans from in vivo, ex vivo and animal models
Godin, Blana
Touitou, Elka
[J]. ADVANCED DRUG DELIVERY REVIEWS, 2007, 59 (11) : 1152 - 1161
[18] Formulation optimization of controlled release diclofenac sodium microspheres using factorial design
Gohel, MC
Amin, AF
[J]. JOURNAL OF CONTROLLED RELEASE, 1998, 51 (2-3) : 115 - 122
[19] Guiling L., 2012, INT J PHARMACEUT, V425, P53
[20] Formulation, Characterization, and Clinical Evaluation of Microemulsion Containing Clotrimazole for Topical Delivery
Hashem, Fahima M.
Shaker, Dalia S.
Ghorab, Mohamed Khalid
Nasr, Mohamed
Ismail, Aliaa
[J]. AAPS PHARMSCITECH, 2011, 12 (03): : 879 - 886

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