Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents

被引：1298

作者：

Galluzzi, Lorenzo ^{[1
,2
,3
,4
,5
]}

Buque, Aitziber ^{[1
,2
,3
,4
,5
]}

Kepp, Oliver ^{[1
,2
,3
,4
,6
]}

Zitvogel, Laurence ^{[5
,7
,8
,9
]}

Kroemer, Guido ^{[1
,2
,3
,4
,6
,10
,11
]}

机构：

[1] Ctr Rech Cordeliers, Equipe Labellisee Ligue Canc 11, F-75006 Paris, France

[2] INSERM, U1138, F-75006 Paris, France

[3] Univ Paris 05, Sorbonne Paris Cite, F-75006 Paris, France

[4] Univ Paris 06, F-75006 Paris, France

[5] Gustave Roussy Comprehens Canc Inst, F-94805 Villejuif, France

[6] Gustave Roussy Comprehens Canc Inst, Metabol & Cell Biol Platforms, F-94805 Villejuif, France

[7] INSERM, U1015, F-94805 Villejuif, France

[8] Ctr Clin Invest Biotherapies Canc CICBT 507, F-94805 Villejuif, France

[9] Univ Paris 11, F-94270 Le Kremlin Bicetre, France

[10] Hop Europeen Georges Pompidou, AP HP, Pole Biol, F-75015 Paris, France

[11] Karolinska Univ Hosp, Karolinska Inst, Dept Womens & Childrens Hlth, S-17176 Stockholm, Sweden

来源：

CANCER CELL | 2015年 / 28卷 / 06期

基金：

欧洲研究理事会;

关键词：

REGULATORY T-CELLS; TUMOR-INFILTRATING LYMPHOCYTES; NATURAL-KILLER-CELLS; GASTROINTESTINAL STROMAL TUMOR; ANTIGEN-PROCESSING MACHINERY; LONG-TERM SURVIVAL; LUNG-CANCER; SUPPRESSOR-CELLS; DENDRITIC CELLS; PD-L1; EXPRESSION;

D O I：

10.1016/j.ccell.2015.10.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The tremendous clinical success of checkpoint blockers illustrates the potential of reestablishing latent immunosurveillance for cancer therapy. Although largely neglected in the clinical practice, accumulating evidence indicates that the efficacy of conventional and targeted anticancer agents does not only involve direct cytostatic/cytotoxic effects, but also relies on the (re)activation of tumor-targeting immune responses. Chemotherapy can promote such responses by increasing the immunogenicity of malignant cells, or by inhibiting immunosuppressive circuitries that are established by developing neoplasms. These immunological "side" effects of chemotherapy are desirable, and their in-depth comprehension will facilitate the design of novel combinatorial regimens with improved clinical efficacy.

引用

页码：690 / 714

页数：25

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