Bog blueberry anthocyanins alleviate photoaging in ultraviolet-B irradiation-induced human dermal fibroblasts

被引:85
作者
Bae, Ji-Young [1 ,2 ]
Lim, Soon Sung [1 ,2 ]
Kim, Sun Ju [3 ]
Choi, Jung-Suk [1 ,2 ]
Park, Jinseu [4 ]
Ju, Sung Mi [4 ]
Han, Seoung Jun [5 ]
Kang, Il-Jun [1 ,2 ]
Kang, Young-Hee [1 ,2 ]
机构
[1] Hallym Univ, Dept Food & Nutr, Chunchon 200702, Kangwon Do, South Korea
[2] Hallym Univ, Korean Inst Nutr, Chunchon 200702, Kangwon Do, South Korea
[3] Hallym Univ, Inst Nat Med, Chunchon 200702, Kangwon Do, South Korea
[4] Hallym Univ, Dept Biomed Sci, Chunchon 200702, Kangwon Do, South Korea
[5] Seorim Bio Co, Hupyung Dong, Chuncheon, South Korea
关键词
Anthocyanin-rich bog blueberry; Human dermal fibroblasts; Matrix metalloproteinase; Photoaging; Ultraviolet-B; FACTOR-KAPPA-B; ACTIVATED PROTEIN-KINASES; GREEN TEA POLYPHENOL; OXIDATIVE STRESS; (-)EPIGALLOCATECHIN GALLATE; MATRIX METALLOPROTEINASES; INDUCED APOPTOSIS; MOUSE SKIN; EXTRACT; DAMAGE;
D O I
10.1002/mnfr.200800245
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Fruits of bog blueberry (Vaccinium uliginosum L.) are rich in anthocyanins that contribute pigmentation. Anthocyanins have received much attention as agents with potentials preventing chronic diseases. This study investigated the capacity of anthocyanin-rich extract from bog blueberry (ATHBBe) to inhibit photoaging in UV-B-irradiated human dermal fibroblasts. BBe anthocyanins were detected as cyanidin-3-glucoside, petunidin-3-glucoside, malvidin-3-glucoside, and delphinidin3-glucoside. ATH-BBe attenuated UV-B-induced toxicity accompanying reactive oxygen species (ROS) production and the resultant DNA damage responsible for activation of p53 and Bad. Preincubation of ATH-BBe markedly suppressed collagen degradation via blunting production of collagenolytic matrix metalloproteinases (MMP). Additionally, ATH-BBe enhanced UV-B-downregulated procollagen expression at transcriptional levels. We next attempted to explore whether ATH-BBe mitigated the MMP-promoted collagen degradation through blocking nuclear factor kappa B (NF-kappa B) activation and MAPK-signaling cascades. UV-B radiation enhanced nuclear translocation of NF-kappa B, which was reversed by treatment with ATH-BBe. The UV-B irradiation rapidly activated apoptosis signal-regulating kinase-1 (ASK-I)-signaling cascades of JNK and p38 mitogen-activated protein kinase (p38 MAPK), whereas ATH-BBe hampered phosphorylation of c-Jun, p53, and signal transducers and activators of transcription-1 (STAT-1) linked to these MAPK signaling pathways. ATH-BBe diminished UV-B augmented-release of inflammatory interleukin (IL)-6 and IL-8. These results demonstrate that ATH-BBe dampens UV-B-triggered collagen destruction and inflammatory responses through modulating NF-kappa B-responsive and MAPK-dependent pathways. Therefore, anthocyanins from edible bog blueberry may be protective against UV-induced skin photoaging.
引用
收藏
页码:726 / 738
页数:13
相关论文
共 50 条
[21]   Effects of the nonsugar fraction of brown sugar on chronic ultraviolet B irradiation-induced photoaging in melanin-possessing hairless mice [J].
Sumiyoshi, Maho ;
Hayashi, Teruaki ;
Kimura, Yoshiyuki .
JOURNAL OF NATURAL MEDICINES, 2009, 63 (02) :130-136
[22]   (-)-Epigallocatechin-3-Gallate Protects Human Skin Fibroblasts from Ultraviolet a Induced Photoaging [J].
Jia, Yuanyuan ;
Mao, Qiuyu ;
Yang, Jingyi ;
Du, Na ;
Zhu, Yuan ;
Min, Wei .
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY, 2023, 16 :149-159
[23]   Ultraviolet-B Protective Effect of Flavonoids from Eugenia caryophylata on Human Dermal Fibroblast Cells [J].
Patwardhan, Juilee ;
Bhatt, Purvi .
PHARMACOGNOSY MAGAZINE, 2015, 11 (44) :S397-S406
[24]   Compounds isolated from Eriobotrya deflexa leaves protect against ultraviolet radiation B-induced photoaging in human fibroblasts [J].
Huang, Chung-Yu ;
Lin, Yi-Tzu ;
Kuo, Hsiang-Chun ;
Chiou, Wen-Fei ;
Lee, Mei-Hsien .
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2017, 175 :244-253
[25]   Schisandrin B protects against solar irradiation-induced oxidative injury in BJ human fibroblasts [J].
Chiu, Po Yee ;
Lam, Philip Y. ;
Yan, Chung Wai ;
Ko, Kam Ming .
FITOTERAPIA, 2011, 82 (04) :682-691
[26]   Annexin A1 protects epidermal stem cells against ultraviolet-B irradiation-induced mitochondrial dysfunction [J].
Ge, Lingzhi ;
Chen, Wenfang ;
Wei, Fangli .
ARCHIVES OF DERMATOLOGICAL RESEARCH, 2024, 316 (07)
[27]   Leptin alleviates ultraviolet-induced skin photoaging in human skin fibroblasts and mice [J].
Zhou, Zhi-Qiang ;
Sui, Zhi-Fu ;
Tian, Yan-Li ;
Zhao, Zhi-Li ;
Shi, Cheng-Fang ;
Liu, Chang ;
Yang, Rong-Ya .
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2016, 9 (02) :1084-1094
[28]   Protective Effects of C24 Ceramide From the Seeds of Brassica napus L. Against Ultraviolet B-Induced Photoaging in Normal Human Dermal Fibroblasts [J].
Kim, Yu M. ;
Bae, Kyung S. .
NATURAL PRODUCT COMMUNICATIONS, 2019, 14 (06)
[29]   MiRNA-27a decreases ultraviolet B irradiation-induced cell damage [J].
Zhang, YuanJing ;
Yang, ChunJun ;
Yang, Sen ;
Guo, Ze .
JOURNAL OF CELLULAR BIOCHEMISTRY, 2020, 121 (02) :1032-1038
[30]   MiR-155 Negatively Regulates c-Jun Expression at the Post-transcriptional Level in Human Dermal Fibroblasts in vitro: Implications in UVA Irradiation-induced Photoaging [J].
Song, Jianwen ;
Liu, Ping ;
Yang, Zhensheng ;
Li, Linli ;
Su, Hui ;
Lu, Ning ;
Peng, Zhenhui .
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2012, 29 (3-4) :331-340