Carriage Rate and Effects of Vaccination after Outbreaks of Serogroup C Meningococcal Disease, Brazil, 2010

被引：31

作者：

Palazzi Safadi, Marco Aurelio ^{[1
]}

Marques Pinto Carvalhanas, Telma Regina ^{[2
]}

de Lemos, Ana Paula ^{[3
]}

Outeiro Gorla, Maria Cecilia ^{[3
]}

Salgado, Maristela ^{[3
]}

Fukasawa, Lucila O. ^{[3
]}

Goncalves, Maria Gisele ^{[3
]}

Higa, Fabio ^{[3
]}

Cunto Brandileone, Maria Cristina ^{[3
]}

Sacchi, Claudio Tavares ^{[3
]}

Ribeiro, Ana Freitas ^{[2
]}

Sato, Helena Keico ^{[2
]}

Bricks, Lucia Ferro ^{[4
]}

de Moraes, Jose Cassio ^{[1
]}

机构：

[1] Fac Ciencias Med Santa Casa, BR-04059060 Sao Paulo, Brazil

[2] Ctr Vigilancia Epidemiol Alexandre Vranjac, Sao Paulo, Brazil

[3] Adolfo Lutz Inst, Sao Paulo, Brazil

[4] Sanofi Pasteur Vaccines, Sao Paulo, Brazil

来源：

EMERGING INFECTIOUS DISEASES | 2014年 / 20卷 / 05期

关键词：

NEISSERIA-MENINGITIDIS C; CONJUGATE VACCINES; HERD-IMMUNITY; POLYSACCHARIDE; IDENTIFICATION; EPIDEMIOLOGY; PREVENTION; CATALONIA; COMMUNITY; CARRIERS;

D O I：

10.3201/eid2005.130948

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During 2010, outbreaks of serogroup C meningococcal (MenC) disease occurred in 2 oil refineries in Sao Paulo State, Brazil, leading to mass vaccination of employees at 1 refinery with a meningococcal polysaccharide A/C vaccine. A cross-sectional study was conducted to assess the prevalence of meningococci carriage among workers at both refineries and to investigate the effect of vaccination on and the,risk factors for pharyngeal carriage of meningococci. Among the vaccinated and nonvaccinated workers, rates of overall meningococci carriage (21.4% and 21.6%, respectively) and of MenC carriage (6.3% and 4.9%, respectively) were similar. However, a MenC strain belonging to The sequence type103 complex predominated and was responsible for the increased incidence of meningococcal disease in Brazil. A low education level was associated with higher risk of meningococci carriage. Polysaccharide vaccination did not affect carriage or interrupt transmission of the epidemic strain. These findings will help inform future vaccination strategies.

引用

页码：806 / 811

页数：6

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