An Acute Ocfentanil Fatality: A Case Report with Postmortem Concentrations

被引：41

作者：

Dussy, F. E. ^{[1
]}

Hangartner, S. ^{[1
]}

Hamberg, C. ^{[1
]}

Berchtold, C. ^{[2
]}

Scherer, U. ^{[2
]}

Schlotterbeck, G. ^{[2
]}

Wyler, D. ^{[3
]}

Briellmann, T. A. ^{[1
]}

机构：

[1] Univ Basel, Inst Legal Med, Forens Chem & Toxicol, Pestalozzistr 22, CH-4056 Basel, Switzerland

[2] Univ Appl Sci Northwestern Switzerland FHNW, Inst Chem & Bioanalyt, Gruendenstr 40, CH-4132 Muttenz, Switzerland

[3] Canton Hosp Grisons, Inst Pathol & Legal Med, Loestr 170, CH-7000 Chur, Switzerland

来源：

JOURNAL OF ANALYTICAL TOXICOLOGY | 2016年 / 40卷 / 09期

关键词：

MASS-SPECTROMETRY; FENTANYL FATALITY; ACETYL FENTANYL; CHROMATOGRAPHY; METABOLITES;

D O I：

10.1093/jat/bkw096

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A 24-year-old man known to consume illegal drugs was found dead in his apartment. A reclosable plastic zipper bag containing several hundred milligrams of a brown powder was found close to the dead body and the first assumption of the investigators was death due to heroin intoxication. Therefore, a legal autopsy was ordered. The following toxicological analysis revealed ocfentanil in urine and in the brown powder. Four different approaches for the determination of the ocfentanil concentrations in peripheral whole blood are described. Enrichment of ocfentanil from the powder was realized. With this reference, it was possible to determine the ocfentanil concentration in the seized powder to be 0.91%. Concentrations of ocfentanil were also determined in the sampled body fluids using the standard addition procedure. In peripheral blood 9.1 mu g/L, in heart blood 27.9 mu g/L and in urine 480 mu g/L were measured. In addition, the antidepressant citalopram, the neuroleptic quetiapine and cannabinoids were found in urine and subsequently quantified in peripheral blood.

引用

页码：761 / 766

页数：6

共 7 条

[1]

[Anonymous], 2011, MASS SPECTRAL GC DAT

[2] Quantification of benzodiazepines in whole blood and serum [J].