Cell Cycle and Developmental Control of Hematopoiesis by Runx1

被引：74
作者：
Friedman, Alan D. [1 ]
机构：
[1] Johns Hopkins Univ, CRB I, Sch Med, Div Pediat Oncol, Baltimore, MD 21231 USA
来源：
JOURNAL OF CELLULAR PHYSIOLOGY | 2009年 / 219卷 / 03期
关键词：
MURINE LEUKEMIA-VIRUS; MYOSIN HEAVY-CHAIN; CBF-BETA-SMMHC; MULTIPLE CHROMOSOMAL TRANSLOCATIONS; STEM-CELL; TRANSCRIPTION FACTOR; AML1; GENE; NUCLEAR FACTOR; DNA-BINDING; FACTOR-I;
D O I：
10.1002/jcp.21738
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Runx1 binds DNA in cooperation with CBF beta to activate or repress transcription, dependent upon cellular context and interaction with a variety of co-activators and co-repressors. Runx1 is required for emergence of adult hematopoietic stem cells (HSC) during embryonic development and for lymphoid, myeloid, and megakaryocyte lineage maturation from HSC in adult marrow. Runx1 levels vary during the cell cycle, and Runx1 regulates G I to S cell cycle progression. Both Cdk and ERK phosphorylate Runx1 to influence its interaction with co-repressors, and the Wnt effector LEF-I/TCF also modulates Runx1 activities. These links likely allow cytokines and signals from adjacent cells to influence HSC proliferation versus quiescence and the rate of progenitor expansion, in response to developmental or environmental demands.
引用
收藏
页码：520 / 524
页数：5
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