AN IN VIVO INTERMEDIATE FILAMENT ASSEMBLY MODEL

被引：8

作者：

Portet, Stephanie ^{[1
]}

Arino, Julien ^{[1
]}

机构：

[1] Univ Manitoba, Dept Math, Winnipeg, MB R3T 2N2, Canada

来源：

MATHEMATICAL BIOSCIENCES AND ENGINEERING | 2009年 / 6卷 / 01期

基金：

加拿大自然科学与工程研究理事会;

关键词：

cytoskeleton assembly dynamics; intermediate filaments; KERATIN-8; PHOSPHORYLATION; NEUROFILAMENT TRANSPORT; EPITHELIAL-CELLS; NETWORKS; VIMENTIN; VITRO; ORGANIZATION; PROTEINS; DYNAMICS; ELEMENTS;

D O I：

10.3934/mbe.2009.6.117

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A model is developed to study the in vivo intermediate filament organization in terms of repartition between four different structural states: soluble proteins, particles, short, and long filaments. An analysis is conducted, showing that the system has a unique, globally asymptotically stable equilibrium. By means of sensitivity analysis, the influence of parameters on the system is studied. It is shown that, in agreement with biological observations, posttranslational modifications of intermediate filament proteins resulting in filament solubilization are the main regulators of the intermediate filament organization. A high signalling-dependent solubilization of filaments favours the intermediate filament aggregation in particles.

引用

页码：117 / 134

页数：18

共 50 条

[21] Impact of N-Terminal Tags on De Novo Vimentin Intermediate Filament Assembly [J].

Usman, Saima ;

Aldehlawi, Hebah ;

Nguyen, Thuan Khanh Ngoc ;

Teh, Muy-Teck ;

Waseem, Ahmad .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (11)

[22] ASSEMBLY OF A TAIL-LESS MUTANT OF THE INTERMEDIATE FILAMENT PROTEIN, VIMENTIN, INVITRO AND INVIVO [J].

ECKELT, A ;

HERRMANN, H ;

FRANKE, WW .

EUROPEAN JOURNAL OF CELL BIOLOGY, 1992, 58 (02) :319-330

[23] The keratin-filament cycle of assembly and disassembly [J].

Koelsch, Anne ;

Windoffer, Reinhard ;

Wuerflinger, Thomas ;

Aach, Til ;

Leube, Rudolf E. .

JOURNAL OF CELL SCIENCE, 2010, 123 (13) :2266-2272

[24] Rapid movements of vimentin on microtubule tracks: Kinesin-dependent assembly of intermediate filament networks [J].

Prahlad, V ;

Yoon, M ;

Moir, RD ;

Vale, RD ;

Goldman, RD .

JOURNAL OF CELL BIOLOGY, 1998, 143 (01) :159-170

[25] Stochastic modeling reveals how motor protein and filament properties affect intermediate filament transport [J].

Dallon, J. C. ;

Leduc, Cecile ;

Etienne-Manneville, Sandrine ;

Portet, Stephanie .

JOURNAL OF THEORETICAL BIOLOGY, 2019, 464 :132-148

[26] Stepwise Characterization of the Thermodynamics of Trichocyte Intermediate Filament Protein Supramolecular Assembly [J].

Ishii, Daisuke ;

Abe, Ryota ;

Watanabe, Shun-ichi ;

Tsuchiya, Masaru ;

Noecker, Bernd ;

Tsumoto, Kouhei .

JOURNAL OF MOLECULAR BIOLOGY, 2011, 408 (05) :832-838

[27] Characterization of distinct early assembly units of different intermediate filament proteins [J].

Herrmann, H ;

Häner, M ;

Brettel, M ;

Ku, NO ;

Aebi, U .

JOURNAL OF MOLECULAR BIOLOGY, 1999, 286 (05) :1403-1420

[28] Characterization of the in vitro co-assembly process of the intermediate filament proteins vimentin and desmin:: mixed polymers at all stages of assembly [J].

Wickert, U ;

Mücke, N ;

Wedig, T ;

Müller, SA ;

Aebi, U ;

Herrmann, H .

EUROPEAN JOURNAL OF CELL BIOLOGY, 2005, 84 (2-3) :379-391

[29] Vimentin Intermediate Filament Formation: In Vitro Measurement and Mathematical Modeling of the Filament Length Distribution during Assembly [J].

Portet, Stephanie ;

Muecke, Norbert ;

Kirmse, Robert ;

Langowski, Joerg ;

Beil, Michael ;

Herrmann, Harald .

LANGMUIR, 2009, 25 (15) :8817-8823

[30] Model of polarization selectivity of the intermediate filament optical channels [J].

Khmelinskii, Igor ;

Zueva, Lidia ;

Inyushin, Michail ;

Makarov, Vladimir .

PHOTONICS AND NANOSTRUCTURES-FUNDAMENTALS AND APPLICATIONS, 2015, 16 :24-33

← 1 2 3 4 5 →