Rhodium-Catalyzed Direct C-H Bond Cyanation of Arenes with Isocyanide

被引：79

作者：

Hong, Xiaohu ^{[1
]}

Wang, Hao ^{[1
]}

Qian, Guangyin ^{[1
]}

Tan, Qitao ^{[1
]}

Xu, Bin ^{[1
,2
,3
]}

机构：

[1] Shanghai Univ, Dept Chem, Innovat Drug Res Ctr, Sch Mat Sci & Engn, Shanghai 200444, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

[3] E China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Dept Chem, Shanghai 200062, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 79卷 / 07期

基金：

中国国家自然科学基金;

关键词：

AROMATIC NITRILES; EFFICIENT ACCESS; TRANSFORMATION; N; N-DIMETHYLFORMAMIDE; HETEROARENES; ISONITRILE; COMPLEXES; AGENT;

D O I：

10.1021/jo500087g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient rhodium-catalyzed regioselective C-H bond cyanation of arenes was developed using tert-butyl isocyanide as the cyanide source. A wide range of (hetero)aryl and cycloalkenyl nitriles could be afforded with high regioselectivity and good functional group tolerance.

引用

页码：3228 / 3237

页数：10

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