Mesenchymal Stem Cell-Derived Apoptotic Bodies: Biological Functions and Therapeutic Potential

被引：35

作者：

Tang, Huixue ^{[1
]}

Luo, Huikun ^{[1
]}

Zhang, Zihan ^{[1
]}

Yang, Di ^{[1
]}

机构：

[1] China Med Univ, Sch & Hosp Stomatol, Liaoning Prov Key Lab Oral Dis, Dept Endodont, Shenyang 110002, Peoples R China

来源：

CELLS | 2022年 / 11卷 / 23期

关键词：

mesenchymal stem cells; apoptosis; apoptotic bodies; extracellular vesicles; EXTRACELLULAR VESICLES; VOLUME DECREASE; EXOSOMES; SECRETOME; PARADIGM; COLITIS; DEATH;

D O I：

10.3390/cells11233879

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mesenchymal stem cells (MSCs) are non-hematopoietic progenitor cells with self-renewal ability and multipotency of osteogenic, chondrogenic, and adipogenic differentiation. MSCs have appeared as a promising approach for tissue regeneration and immune therapies, which are attributable not only to their differentiation into the desired cells but also to their paracrine secretion. MSC-sourced secretome consists of soluble components including growth factors, chemokines, cytokines, and encapsulated extracellular vesicles (EVs). Apoptotic bodies (ABs) are large EVs (diameter 500-2000 nm) harboring a variety of cellular components including microRNA, mRNA, DNA, protein, and lipids related to the characteristics of the originating cell, which are generated during apoptosis. The released ABs as well as the genetic information they carry are engulfed by target cells such as macrophages, dendritic cells, epithelial cells, and fibroblasts, and subsequently internalized and degraded in the lysosomes, suggesting their ability to facilitate intercellular communication. In this review, we discuss the current understanding of the biological functions and therapeutic potential of MSC-derived ABs, including immunomodulation, tissue regeneration, regulation of inflammatory response, and drug delivery system.

引用

页数：10

共 80 条

[11] Fate decision of mesenchymal stem cells: adipocytes or osteoblasts? [J].

Chen, Q. ;

Shou, P. ;

Zheng, C. ;

Jiang, M. ;

Cao, G. ;

Yang, Q. ;

Cao, J. ;

Xie, N. ;

Velletri, T. ;

Zhang, X. ;

Xu, C. ;

Zhang, L. ;

Yang, H. ;

Hou, J. ;

Wang, Y. ;

Shi, Y. .

CELL DEATH AND DIFFERENTIATION, 2016, 23 (07) :1128-1139

[12] Exosomes derived from human adipose tissue-derived mesenchymal stem cells alleviate atopic dermatitis [J].

Cho, Byong Seung ;

Kim, Jin Ock ;

Ha, Dae Hyun ;

Yi, Yong Weon .

STEM CELL RESEARCH & THERAPY, 2018, 9

[13] Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles [J].

Colombo, Marina ;

Raposo, Graca ;

Thery, Clotilde .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30, 2014, 30 :255-289

[14] Growth, differentiation capacity, and function of mesenchymal stem cells expanded in serum-free medium developed via combinatorial screening [J].

Crapnell, Kirsten ;

Blaesius, Rainer ;

Hastings, Abel ;

Lennon, Donald P. ;

Caplan, Arnold I. ;

Bruder, Scott P. .

EXPERIMENTAL CELL RESEARCH, 2013, 319 (10) :1409-1418

[15] Actin-myosin-based contraction is responsible for apoptotic nuclear disintegration [J].

Croft, DR ;

Coleman, ML ;

Li, SX ;

Robertson, D ;

Sullivan, T ;

Stewart, CL ;

Olson, MF .

JOURNAL OF CELL BIOLOGY, 2005, 168 (02) :245-255

[16] Future Perspectives on the Role of Stem Cells and Extracellular Vesicles in Vascular Tissue Regeneration [J].

Cunnane, Eoghan M. ;

Weinbaum, Justin S. ;

O'Brien, Fergal J. ;

Vorp, David A. .

FRONTIERS IN CARDIOVASCULAR MEDICINE, 2018, 5

[17] Cell death: a review of the major forms of apoptosis, necrosis and autophagy [J].

D'Arcy, Mark S. .

CELL BIOLOGY INTERNATIONAL, 2019, 43 (06) :582-592

[18] Chimeric apoptotic bodies functionalized with natural membrane and modular delivery system for inflammation modulation [J].

Dou, Geng ;

Tian, Ran ;

Liu, Xuemei ;

Yuan, Pingyun ;

Ye, Qianwen ;

Liu, Jin ;

Liu, Siying ;

Zhou, Jun ;

Deng, Zhihong ;

Chen, Xin ;

Liu, Shiyu ;

Jin, Yan .

SCIENCE ADVANCES, 2020, 6 (30)

[19] Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis [J].

Doyle, Laura M. ;

Wang, Michael Zhuo .

CELLS, 2019, 8 (07)

[20] Emerging understanding of apoptosis in mediating mesenchymal stem cell therapy [J].

Fu, Yu ;

Sui, Bingdong ;

Xiang, Lei ;

Yan, Xutong ;

Wu, Di ;

Shi, Songtao ;

Hu, Xuefeng .

CELL DEATH & DISEASE, 2021, 12 (06)

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