Nickel-Catalyzed Synthesis of Oxazoles via C-S Activation

被引：87

作者：

Lee, Kyoungsoo ^{[1
]}

Counceller, Carla M. ^{[1
]}

Stambuli, James P. ^{[1
]}

机构：

[1] Ohio State Univ, Dept Chem, Evans Chem Labs, Columbus, OH 43210 USA

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 06期

关键词：

CROSS-COUPLING REACTION; OXIDATIVE ADDITION; DIAZONAMIDE; DERIVATIVES;

D O I：

10.1021/ol900260g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 2-substituted oxazoles is achieved via nickel-catalyzed cross-coupling reaction of 2-methylthio-oxazole and various organozinc reagents. An extension of this method is demonstrated with a chemoselective, one-pot synthesis of unsymmetrical 2,5-disubstituted oxazoles. This synthesis of 2- and 2,5-substituted oxazoles using this method provides great advantages over previous methods for these compounds and is highly complementary to current cyclodehydration strategies.

引用

页码：1457 / 1459

页数：3

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