Clinical significance of myositis-specific autoantibody profiles in Japanese patients with polymyositis/dermatomyositis

被引：50
作者：
Temmoku, Jumpei [1 ]
Sato, Shuzo [1 ]
Fujita, Yuya [1 ]
Asano, Tomoyuki [1 ]
Suzuki, Eiji [2 ]
Kanno, Takashi [2 ]
Furuya, Makiko Yashiro [1 ]
Matsuoka, Naoki [1 ]
Kobayashi, Hiroko [1 ]
Watanabe, Hiroshi [1 ]
Koga, Tomohiro [3 ]
Shimizu, Toshimasa [3 ]
Kawakami, Atsushi [3 ]
Migita, Kiyoshi [1 ]
机构：
[1] Fukushima Med Univ, Sch Med, Dept Rheumatol, 1 Hikarigaoka, Fukushima, Fukushima 9601295, Japan
[2] Ohta Nishinouchi Gen Hosp Fdn, Dept Rheumatol, Koriyama, Fukushima, Japan
[3] Nagasaki Univ, Grad Sch Biomed Sci, Unit Translat Med, Dept Immunol & Rheumatol, Nagasaki, Japan
来源：
MEDICINE | 2019年 / 98卷 / 20期
基金：
日本学术振兴会;
关键词：
anti-MDA5; antibody; anti-SSA/Ro52; dermatomyositis; myositis-specific autoantibody; polymyositis; INTERSTITIAL LUNG-DISEASE; RNA SYNTHETASE ANTIBODIES; GENE; 5; DERMATOMYOSITIS; POLYMYOSITIS; ASSOCIATION; PROGNOSIS; RELAPSE; UTILITY; RISK;
D O I：
10.1097/MD.0000000000015578
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Myositis-specific autoantibodies, such as anti-melanoma differentiation associated gene 5 (MDA5) and anti-anti-amino acyl-tRNA synthetases (ARS) antibodies, are associated with interstitial lung diseases (ILD), which determine the prognosis of polymyositis/dermatomyositis (PM/DM) patients. However, there is a paucity of data on the clinical correlation between anti-Sjogren syndrome-related antigen A (anti-SSA)/Ro52 antibodies in PM/DM. We investigated the prevalence of myositis-specific autoantibodies including anti-SSA/Ro52 antibody and assessed the clinical significance of these antibodies in patients with PM/DM. We retrospectively reviewed demographic data and clinical outcomes in patients with PM/DM. The study population comprised 24 patients with PM and 60 patients with DM. The presence of anti-myositis-specific antibodies (MDA5, ARS, Jo-1, SSA/Ro52) was determined by immunosorbent assay (ELISA). Anti-MDA5 antibody was detected in 18 patients with DM (n= 60). Anti-ARS/anti-SSA/Ro52 antibodies were detected in 31 and 39 patients with PM/DM (n= 84). Rapidly progressive ILD patients were mainly found in the anti-MDA5 antibody-positive DM group. During the follow-up period, 9 patients died. Kaplan-Meier analysis demonstrated that survival rates seem to be lower in DM patients with anti-MDA5 antibodies compared with those without anti-MDA5 antibodies. Furthermore, dual positivity for anti-SSA/Ro52 and anti-MDA5 antibodies was significantly higher in nonsurviving DM patients compared with survivors. Although the presence of anti-ARS or anti-MDA5 antibodies is a prognostic marker in patients with PM/DM, combined presence of anti-SSA/Ro52 and anti-MDA5 antibodies represent another marker for clinical outcome in DM patients. Our results suggest that anti-SSA/Ro52 antibody positivity in DM patients with anti-MDA5 antibody reveals a subgroup of DM patients with poor prognosis.
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页数：8
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