Synthesis, characterization and anticancer properties of (salicylaldiminato) platinum(II) complexes

被引:25
作者
Patterson, Alyssa E. [1 ]
Miller, Jessica J. [1 ]
Miles, Brittany A. [1 ]
Stewart, Erin L. [1 ]
Melanson, Josee-Marie E. J. [1 ]
Vogels, Christopher M. [1 ]
Cockshutt, Amanda M. [1 ]
Decken, Andreas [2 ]
Morin, Pier, Jr. [3 ]
Westcott, Stephen A. [1 ]
机构
[1] Mt Allison Univ, Dept Chem & Biochem, Sackville, NB E4L 1G8, Canada
[2] Univ New Brunswick, Dept Chem, Fredericton, NB E3B 5A3, Canada
[3] Univ Moncton, Dept Chim & Biochim, Moncton, NB E1A 3E9, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
Cancer; Glioma; Platinum; Salicylaldimine; Schiff base; IN-VITRO; CISPLATIN; LIGANDS; PALLADIUM(II);
D O I
10.1016/j.ica.2014.02.028
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Twelve new (salicylaldiminato) platinum(II) complexes have been prepared, characterized and examined for their in vitro cytotoxic properties against three human glioma cell lines LN18, LN405 and Hs683. Initial biotesting was done on platinum complexes 1-6, which display a wide range of physicochemical properties. Whereas introduction of aromatic rings in the complexes did not seem to have a significant impact on bioactivities, the length of the aliphatic group positively correlated with cytotoxicity in all cell lines. Complexes 2 and 3 were found to be particularly potent against LN18 cells as demonstrated by stronger cell growth inhibition when compared to cisplatin. These initial findings led us to develop an additional series of mono (salicylaldiminato) platinum(II) complexes 7-12, which were subjected to additional cytotoxicity studies but were less cytotoxic compared to the bis Schiff base complexes. These organometallic compounds could serve as interesting starting points for the development of novel therapeutic strategies to treat brain tumors. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码:88 / 94
页数:7
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