Polyphenol intake and differentiated thyroid cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

被引：24

作者：

Zamora-Ros, Raul ^{[1
]}

Cayssials, Valerie ^{[1
,2
]}

Franceschi, Silvia ^{[3
]}

Kyro, Cecilie ^{[4
]}

Weiderpass, Elisabete ^{[5
]}

Hennings, Joakim ^{[6
]}

Sandstrom, Maria ^{[7
]}

Tjonneland, Anne ^{[4
]}

Olsen, Anja ^{[4
]}

Overvad, Kim ^{[8
]}

Boutron-Ruault, Marie-Christine ^{[9
,10
]}

Truong, Therese ^{[11
]}

Mancini, Francesca Romana ^{[9
,10
]}

Katzke, Verena ^{[12
]}

Kuehn, Tilman ^{[12
]}

Boeing, Heiner ^{[13
]}

Trichopoulou, Antonia ^{[14
]}

Karakatsani, Anna ^{[14
,15
]}

Martimianaki, Georgia ^{[14
]}

Palli, Domenico ^{[16
]}

Krogh, Vittorio ^{[17
]}

Panico, Salvatore ^{[18
]}

Tumino, Rosario ^{[19
]}

Sacerdote, Carlotta ^{[20
,21
]}

Lasheras, Cristina ^{[22
]}

Rodriguez-Barranco, Miguel ^{[23
,24
]}

Amiano, Pilar ^{[24
,25
]}

Colorado-Yohar, Sandra M. ^{[24
,26
,27
]}

Ardanaz, Eva ^{[24
,28
,29
]}

Almquist, Martin ^{[30
]}

Ericson, Ulrika ^{[31
]}

Bueno-de-Mesquita, H. Bas ^{[32
,33
,34
,35
]}

Vermeulen, Roel ^{[36
,37
]}

Schmidt, Julie A. ^{[38
]}

Byrnes, Graham ^{[5
]}

Scalbert, Augustin ^{[5
]}

Agudo, Antonio ^{[1
]}

Rinaldi, Sabina ^{[5
]}

机构：

[1] Bellvitge Biomed Res Inst IDIBELL, Catalan Inst Oncol, Unit Nutr & Canc, Canc Epidemiol Res Program, Barcelona, Spain

[2] Univ Republica, Fac Vet, Dept Bioestadist, Montevideo, Uruguay

[3] CRO Aviano Natl Canc Inst IRCCS, Aviano, Italy

[4] Danish Canc Soc Res Ctr, Unit Diet Genes & Environm, Copenhagen, Denmark

[5] IARC, Lyon, France

[6] Umea Univ, Dept Surg & Perioperat Sci, Umea, Sweden

[7] Umea Univ, Dept Radiat Sci, Umea, Sweden

[8] Aarhus Univ, Dept Publ Hlth, Sect Epidemiol, Aarhus, Denmark

[9] Univ Paris Saclay, Univ Paris Sud, Fac Med, INSERM,UVSQ,CESP, Villejuif, France

[10] Inst Gustave Roussy, Villejuif, France

[11] Univ Paris Saclay, Univ Paris Sud, Ctr Res Epidemiol & Populat Hlth CESP, Canc & Environm Team,INSERM, Villejuif, France

[12] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[13] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany

[14] Hellen Hlth Fdn, Athens, Greece

[15] Natl & Kapodistrian Univ Athens, ATTIKON Univ Hosp, Sch Med, Pulm Med Dept 2, Haidari, Greece

[16] Inst Canc Res Prevent & Clin Network ISPRO, Canc Risk Factors & Life Style Epidemiol Unit, Florence, Italy

[17] Fdn IRCCS Ist Nazl Tumori, Nutr Epidemiol Unit, Milan, Italy

[18] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[19] Civ MP Arezzo Hosp, Canc Registry & Histopathol Unit, ASP, Ragusa, Italy

[20] Citta Salute & Scienza Univ Hosp, Unit Canc Epidemiol, Turin, Italy

[21] Ctr Canc Prevent CPO, Turin, Italy

[22] Univ Oviedo, Dept Funct Biol, Fac Med, Oviedo, Spain

[23] Univ Granada, Escuela Andaluza Salud Publ, Inst Invest Biosanitaria Ibs GRANADA, Granada, Spain

[24] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain

[25] BioDonostia Res Inst, Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[26] IMIB Arrixaca, Dept Epidemiol, Murcia Reg Hlth Council, Murcia, Spain

[27] Univ Antioquia, Natl Fac Publ Hlth, Res Grp Demog & Hlth, Medellin, Colombia

[28] Navarra Publ Hlth Inst, Pamplona, Spain

[29] Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain

[30] Lund Univ, Skane Univ Hosp Malmo, Dept Surg, Lund, Sweden

[31] Lund Univ, Dept Clin Sci, Genet Epidemiol, Diabet & Cardiovasc Dis, Malmo, Sweden

[32] Natl Inst Publ Hlth & Environm RIVM, Dept Determinants Chron Dis DCD, Bilthoven, Netherlands

[33] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[34] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[35] Univ Malaya, Fac Med, Dept Social & Prevent Med, Kuala Lumpur, Malaysia

[36] Univ Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands

[37] Univ Med Ctr Utrecht, Dept Publ Hlth, Utrecht, Netherlands

[38] Univ Oxford, Canc Epidemiol Unit, Oxford, England

来源：

INTERNATIONAL JOURNAL OF CANCER | 2020年 / 146卷 / 07期

基金：

欧洲研究理事会; 英国医学研究理事会; 瑞典研究理事会;

关键词：

polyphenols; flavonoids; intake; thyroid cancer; cohort; EPIC; LOW-GRADE INFLAMMATION; CARCINOMA; CONSUMPTION; VALIDITY;

D O I：

10.1002/ijc.32589

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Polyphenols are bioactive compounds with several anticarcinogenic activities; however, human data regarding associations with thyroid cancer (TC) is still negligible. Our aim was to evaluate the association between intakes of total, classes and subclasses of polyphenols and risk of differentiated TC and its main subtypes, papillary and follicular, in a European population. The European Prospective Investigation into Cancer and Nutrition cohort included 476,108 men and women from 10 European countries. During a mean follow-up of 14 years, there were 748 incident differentiated TC cases, including 601 papillary and 109 follicular tumors. Polyphenol intake was estimated at baseline using validated center/country-specific dietary questionnaires and the Phenol-Explorer database. In multivariable-adjusted Cox regression models, no association between total polyphenol and the risks of overall differentiated TC (HRQ4 vs. Q1 = 0.99, 95% confidence interval [CI] 0.77-1.29), papillary (HRQ4 vs. Q1 = 1.06, 95% CI 0.80-1.41) or follicular TC (HRQ4 vs. Q1 = 1.10, 95% CI 0.55-2.22) were found. No associations were observed either for flavonoids, phenolic acids or the rest of classes and subclasses of polyphenols. After stratification by body mass index (BMI), an inverse association between the intake of polyphenols (p-trend = 0.019) and phenolic acids (p-trend = 0.007) and differentiated TC risk in subjects with BMI >= 25 was observed. In conclusion, our study showed no associations between dietary polyphenol intake and differentiated TC risk; although further studies are warranted to investigate the potential protective associations in overweight and obese individuals.

引用

页码：1841 / 1850

页数：10

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