Advances in cellular and humoral immunotherapy - implications for the treatment of poor risk childhood, adolescent, and young adult B-cell non-Hodgkin lymphoma

被引：18
作者：
Chu, Yaya [1 ]
Gardenswartz, Aliza [1 ]
Termuhlen, Amanda M. [2 ]
Cairo, Mitchell S. [1 ,3 ,4 ,5 ,6 ]
机构：
[1] New York Med Coll, Dept Pediat, Valhalla, NY 10595 USA
[2] Univ Minnesota, Sch Med, Dept Pediat, Minneapolis, MN 55455 USA
[3] New York Med Coll, Dept Med, Valhalla, NY 10595 USA
[4] New York Med Coll, Dept Pathol, Valhalla, NY 10595 USA
[5] New York Med Coll, Dept Microbiol & Immunol, Valhalla, NY 10595 USA
[6] New York Med Coll, Dept Cell Biol & Anat, Valhalla, NY 10595 USA
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2019年 / 185卷 / 06期
关键词：
cellular immunotherapy; chimeric antigen receptor; B-cell non-Hodgkin lymphoma; stem cell transplantation; IL-15; superagonist; NATURAL-KILLER-CELLS; BONE-MARROW-TRANSPLANTATION; CAR-T-CELLS; HIGH-DOSE CHEMOTHERAPY; ACUTE-LYMPHOBLASTIC-LEUKEMIA; PHASE-II TRIAL; OBINUTUZUMAB GA101; PEDIATRIC-PATIENTS; IL-15; SUPERAGONIST; CD20; ANTIBODY;
D O I：
10.1111/bjh.15753
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Patients with relapsed, refractory or advanced stage B non-Hodgkin lymphoma (NHL) continue to have a dismal prognosis. This review summarises current and novel cellular and immunotherapy for these high-risk populations, including haematopoietic stem cell transplant, bispecific antibodies, viral-derived cytotoxic T cells, chimeric antigen receptor (CAR) T cells, and natural killer (NK) cell therapy, as discussed at the 6th International Symposium on Childhood, Adolescent and Young Adult Non-Hodgkin Lymphoma on September 26th-29th 2018 in Rotterdam, the Netherlands, and explores the future of NK/CAR NK therapies.
引用
收藏
页码：1055 / 1070
页数：16
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