The Principles of Engineering Immune Cells to Treat Cancer

被引：827
|
作者：
Lim, Wendell A. [1 ]
June, Carl H. [2 ,3 ]
机构：
[1] Univ Calif San Francisco, Howard Hughes Med Inst, Dept Cellular & Mol Pharmacol, UCSF Ctr Syst & Synthet Biol, San Francisco, CA 94158 USA
[2] Univ Penn, Dept Pathol & Lab Med, Ctr Cellular Immunotherapies, Perelman Sch Med, Philadelphia, PA 19104 USA
[3] Univ Penn, Parker Inst Canc Immunotherapy, Philadelphia, PA 19104 USA
来源：
CELL | 2017年 / 168卷 / 04期
关键词：
CHIMERIC ANTIGEN RECEPTOR; CD8(+) T-CELLS; SERIOUS ADVERSE EVENT; ANTITUMOR-ACTIVITY; B-CELL; ADOPTIVE TRANSFER; CARDIOVASCULAR TOXICITY; METASTATIC MELANOMA; TUMOR-ANTIGENS; HOST-DISEASE;
D O I：
10.1016/j.cell.2017.01.016
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chimeric antigen receptor (CAR) T cells have proven that engineered immune cells can serve as a powerful new class of cancer therapeutics. Clinical experience has helped to define the major challenges that must be met to make engineered T cells a reliable, safe, and effective platform that can be deployed against a broad range of tumors. The emergence of synthetic biology approaches for cellular engineering is providing us with a broadly expanded set of tools for programming immune cells. We discuss how these tools could be used to design the next generation of smart T cell precision therapeutics.
引用
收藏
页码：724 / 740
页数：17
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