Ataxin-2 Is Droppin' Some Knowledge

被引：9

作者：

Becker, Lindsay A. ^{[1
,2
]}

Gitler, Aaron D. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Neurosci Grad Program, Stanford, CA 94305 USA

来源：

NEURON | 2018年 / 98卷 / 04期

关键词：

STRESS GRANULES; PROTEIN; MICE; ALS;

D O I：

10.1016/j.neuron.2018.05.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Ataxin-2 is an RNA-binding protein involved in translation regulation and mutated in neurodegenerative diseases, including ALS. In this issue of Neuron, Bakthavachalu et al. (2018) demonstrate that higher-order ataxin-2 RNA/protein assemblies are necessary for both translation-dependent learning and ALS-associated neurodegeneration in Drosophila.

引用

页码：673 / 675

页数：3

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