Ataxin-2 Is Droppin' Some Knowledge

被引：9
作者：
Becker, Lindsay A. [1 ,2 ]
Gitler, Aaron D. [1 ]
机构：
[1] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Neurosci Grad Program, Stanford, CA 94305 USA
来源：
NEURON | 2018年 / 98卷 / 04期
关键词：
STRESS GRANULES; PROTEIN; MICE; ALS;
D O I：
10.1016/j.neuron.2018.05.002
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Ataxin-2 is an RNA-binding protein involved in translation regulation and mutated in neurodegenerative diseases, including ALS. In this issue of Neuron, Bakthavachalu et al. (2018) demonstrate that higher-order ataxin-2 RNA/protein assemblies are necessary for both translation-dependent learning and ALS-associated neurodegeneration in Drosophila.
引用
收藏
页码：673 / 675
页数：3
相关论文
共 50 条
  • [21] Ataxin-2 sequesters Raptor into aggregates and impairs cellular mTORC1 signaling
    Liu, Ya-Jun
    Wang, Jian-Yang
    Zhang, Xiang-Le
    Jiang, Lei-Lei
    Hu, Hong-Yu
    FEBS JOURNAL, 2024, 291 (08) : 1795 - 1812
  • [22] Mitigating a TDP-43 proteinopathy by targeting ataxin-2 using RNA-targeting CRISPR effector proteins
    Zeballos, C. M. Alejandra
    Moore, Hayden J.
    Smith, Tyler J.
    Powell, Jackson E.
    Ahsan, Najah S.
    Zhang, Sijia
    Gaj, Thomas
    NATURE COMMUNICATIONS, 2023, 14 (01)
  • [23] The LSmAD Domain of Ataxin-2 Modulates the Structure and RNA Binding of Its Preceding LSm Domain
    Zhang, Shengping
    Zhang, Yunlong
    Chen, Ting
    Hu, Hong-Yu
    Lu, Changrui
    CELLS, 2025, 14 (05)
  • [24] Ataxin-2 as potential disease modifier in C9ORF72 expansion carriers
    Van Blitterswijk, Marka
    Mullen, Bianca
    Heckman, Michael G.
    Baker, Matthew C.
    DeJesus-Hernandez, Mariely
    Brown, Patricia H.
    Murray, Melissa E.
    Hsiung, Ging-Yuek R.
    Stewart, Heather
    Karydas, Anna M.
    Finger, Elizabeth
    Kertesz, Andrew
    Bigio, Eileen H.
    Weintraub, Sandra
    Mesulam, Marsel
    Hatanpaa, Kimmo J.
    White, Charles L., III
    Neumann, Manuela
    Strong, Michael J.
    Beach, Thomas G.
    Wszolek, Zbigniew K.
    Lippa, Carol
    Caselli, Richard
    Petrucelli, Leonard
    Josephs, Keith A.
    Parisi, Joseph E.
    Knopman, David S.
    Petersen, Ronald C.
    Mackenzie, Ian R.
    Seeley, William W.
    Grinberg, Lea T.
    Miller, Bruce L.
    Boylan, Kevin B.
    Graff-Radford, Neill R.
    Boeve, Bradley F.
    Dickson, Dennis W.
    Rademakers, Rosa
    NEUROBIOLOGY OF AGING, 2014, 35 (10) : 2421.e13 - 2421.e17
  • [25] Structured and disordered regions of Ataxin-2 contribute differently to the specificity and efficiency of mRNP granule formation
    Petrauskas, Arnas
    Fortunati, Daniel L.
    Kandi, Arvind Reddy
    Pothapragada, Sai Shruti
    Agrawal, Khushboo
    Singh, Amanjot
    Huelsmeier, Joern
    Hillebrand, Jens
    Brown, Georgia
    Chaturvedi, Dhananjay
    Lee, Jongbo
    Lim, Chunghun
    Auburger, Georg
    Vijayraghavan, K.
    Ramaswami, Mani
    Bakthavachalu, Baskar
    PLOS GENETICS, 2024, 20 (05):
  • [26] Impact of Ataxin-2 knock out on circadian locomotor behavior and PER immunoreaction in the SCN of mice
    Pfeffer, Martina
    Gispert, Suzana
    Auburger, Georg
    Wicht, Helmut
    Korf, Horst-Werner
    CHRONOBIOLOGY INTERNATIONAL, 2017, 34 (01) : 129 - 137
  • [27] Pbp1, the yeast ortholog of human Ataxin-2, functions in the cell growth on non-fermentable carbon sources
    Dang Thi Tuong Vi
    Fujii, Shiori
    Valderrama, Arvin Lapiz
    Ito, Ayaka
    Matsuura, Eri
    Nishihata, Ayaka
    Irie, Kaoru
    Suda, Yasuyuki
    Mizuno, Tomoaki
    Irie, Kenji
    PLOS ONE, 2021, 16 (05):
  • [28] Ataxin-2 polyglutamine expansions aberrantly sequester TDP-43 ribonucleoprotein condensates disrupting mRNA transport and local translation in neurons
    Wijegunawardana, Authors Denethi
    Nayak, Asima
    Vishal, Sonali S.
    Venkatesh, Neha
    Gopal, Pallavi P.
    DEVELOPMENTAL CELL, 2025, 60 (02) : 253 - 269.e5
  • [29] FMRP and Ataxin-2 function together in long-term olfactory habituation and neuronal translational control
    Sudhakaran, Indulekha P.
    Hillebrand, Jens
    Dervan, Adrian
    Das, Sudeshna
    Holohan, Eimear E.
    Huelsmeier, Joern
    Sarov, Mihail
    Parker, Roy
    VijayRaghavan, K.
    Ramaswami, Mani
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (01) : E99 - E108
  • [30] TR-FRET-Based Immunoassay to Measure Ataxin-2 as a Target Engagement Marker in Spinocerebellar Ataxia Type 2
    Bux, Jessica
    Sen, Nesli Ece
    Klink, Isa-Maria
    Hauser, Stefan
    Synofzik, Matthis
    Schoels, Ludger
    Auburger, Georg
    Riess, Olaf
    Huebener-Schmid, Jeannette
    MOLECULAR NEUROBIOLOGY, 2023, 60 (06) : 3553 - 3567
12345