Ataxin-2 Is Droppin' Some Knowledge

被引：9
|
作者：
Becker, Lindsay A. [1 ,2 ]
Gitler, Aaron D. [1 ]
机构：
[1] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Neurosci Grad Program, Stanford, CA 94305 USA
来源：
NEURON | 2018年 / 98卷 / 04期
关键词：
STRESS GRANULES; PROTEIN; MICE; ALS;
D O I：
10.1016/j.neuron.2018.05.002
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Ataxin-2 is an RNA-binding protein involved in translation regulation and mutated in neurodegenerative diseases, including ALS. In this issue of Neuron, Bakthavachalu et al. (2018) demonstrate that higher-order ataxin-2 RNA/protein assemblies are necessary for both translation-dependent learning and ALS-associated neurodegeneration in Drosophila.
引用
收藏
页码：673 / 675
页数：3
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