Multidisciplinary Approach of Lumbo-Sacral Chordoma: From Oncological Treatment to Reconstructive Surgery

被引：25

作者：

Garofalo, Fabio ^{[1
]}

di Summa, Pietro G. ^{[2
]}

Christoforidis, Dimitrios ^{[1
,3
]}

Pracht, Marc ^{[4
]}

Laudato, Pietro ^{[5
]}

Cherix, Ephane ^{[5
]}

Bouchaab, Hanan ^{[6
]}

Raffoul, Wassim ^{[2
]}

Demartines, Nicolas ^{[1
]}

Matter, Maurice ^{[1
]}

机构：

[1] Univ Hosp Lausanne CHUV, Dept Visceral Surg, CH-1011 Lausanne, Switzerland

[2] Univ Hosp Lausanne CHUV, Dept Plast & Reconstruct Surg, CH-1011 Lausanne, Switzerland

[3] Hosp Civ, Dept Surg, Lugano, Switzerland

[4] Univ Hosp Lausanne CHUV, Dept Oncol, CH-1011 Lausanne, Switzerland

[5] Univ Hosp Lausanne CHUV, Dept Orthoped, CH-1011 Lausanne, Switzerland

[6] Univ Hosp Lausanne CHUV, Dept Radiooncol, CH-1011 Lausanne, Switzerland

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2015年 / 112卷 / 05期

关键词：

sacrum; chordoma; spine; EN-BLOC SPONDYLECTOMY; CARBON ION RADIOTHERAPY; GROWTH-FACTOR RECEPTOR; TERM-FOLLOW-UP; MALIGNANT-TUMORS; SACRAL CHORDOMA; PHASE-II; PELVIC RECONSTRUCTION; ABDOMINOPERINEAL EXCISION; INTRACRANIAL CHORDOMA;

D O I：

10.1002/jso.24026

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lumbo-sacral chordoma is a rare, slow-growing tumor, arising from embryonic nothocordal remnants. Wide en bloc excision with clear margins remains mandatory to achieve satisfactory recurrence rates and disease-free survival. No chemotherapy has been demonstrated to be effective and radiotherapy is only marginally effective. Tyrosine kinase receptor inhibitors have showed encouraging results in locally advanced and metastatic chordoma. Reconstructive surgery may become very complex. Multidisciplinary approach in tertiary hospitals is always necessary. (C) 2015 Wiley Periodicals, Inc.

引用

页码：544 / 554

页数：11

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