Role of nitric oxide in the control of the heart rate within the nucleus ambiguus of rats

被引：23
作者：
Ruggeri, P
Battaglia, A
Ermirio, R
Grossini, E
Molinari, C
Mary, DASG
Vacca, G
机构：
[1] Univ Genoa, Fac Med & Chirurg, Dipartimento Med Sperimentale, I-16132 Genoa, Italy
[2] Univ Piemonte Orientale A Avogadro, Fac Med & Chirurg, Dipartimento Sci Med, I-28100 Novara, Italy
[3] Univ Leeds, Inst Cardiovasc Res, Leeds LS2 9JT, W Yorkshire, England
来源：
NEUROREPORT | 2000年 / 11卷 / 03期
关键词：
autonomic nervous system; heart rate; medulla oblongata; nitric oxide; nucleus ambiguus;
D O I：
10.1097/00001756-200002280-00011
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The aim of this study was to determine whether NO plays a role in the control of heart rate (HR) within the nucleus ambiguus (NA). Experiments were performed in 29 male Wistar rats anaesthetized with urethane. Microinjections of the NO-donor sodium nitroprusside (SNP; 5 mmol) as well as of L-arginine (L-arg; 50 mmol) into functionally identified cardioinhibitory sites within the NA significantly decreased HR (-57.7 +/- 8.4 and -53.8 +/- 3.2 bpm, respectively), whereas the NO-synthase inhibitor N-omega-nitro-L-arginine methyl ester (L-NAME) significantly increased HR (+40 +/- 2.7 bpm). Bilateral vagotomy and i.v. injection of atropine (0.5 mg/kg) always abolished the: HR decrease induced by SNP and L-arg, whereas propranolol did not affect the HR responses. These results demonstrated that NO mechanisms within the NA play a role in the parasympathetic control of the HR. NeuroReport 11:481-485 (C) 2000 Lippincott Williams & Wilkins.
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收藏
页码：481 / 485
页数：5
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